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- Research interviews
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1. The regulation of cell therapy- Prof. Moutih Rafei
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17 min
2. How and why neurons die in Alzheimer's disease?- Prof. Bart De Strooper
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11 min
3. The future of blood tests in cancer treatment- Dr. Isaac Garcia-Murillas
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4. Role of marketing authorization holder in drug safety- Dr. Raphael Elmadjian Pareschi
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25 min
5. Synthetic whole embryo models and their applications- Prof. Jacob (Yaqub) Hanna
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31 min
6. Scale-up challenges in the production of nanomedicines from lab to industry- Prof. Dr. Oya Tagit
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14 min
7. Artificial intelligence in precision medicine- Dr. Michael P. Menden
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30 min
8. Translational medicine: the risk of failure in delay and how to reduce it- Prof. Martin Wehling
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8 min
9. Challenges and solutions of scaling up- Dr. Shaukat Ali
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15 min
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31 min
11. Management of generic drug development: challenges and opportunities- Mr. Sandeep Patil
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10 min
12. MassBank development and future- Dr. Emma L. Schymanski
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31 min
13. Elite controllers of HIV: from discovery to future therapies- Prof. Bruce Walker
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25 min
14. Translational research in amyotrophic lateral sclerosis (ALS)- Prof. Aaron D. Gitler
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10 min
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25 min
16. PANDAS: a potential link between group A streptococcal infections and neurological disorders- Prof. P. Patrick Cleary
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29 min
17. Rheumatic diseases and musculoskeletal pain- Prof. Anisur Rahman
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23 min
18. Towards developing a universal influenza vaccine- Prof. Peter Palese
- Clinical interviews
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21 min
19. Monkeypox: etiopathogenesis, prevention, and treatments- Dr. Dennis Hruby
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13 min
20. Kidney xenotransplantation- Dr. Douglas J. Anderson
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28 min
21. CAR-T and TCR-T cellular immunotherapies in oncology- Prof. Sebastian Kobold
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28 min
22. MAPS: the business of medical affairs- Dr. Danie du Plessis
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26 min
23. Hypertrophic cardiomyopathy: therapies and treatments- Prof. Srihari Naidu
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24 min
24. Combating the HIV epidemic- Prof. William Blattner
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17 min
25. Epigenetic pharmaceuticals used in the clinic- Dr. Thomas Paul
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21 min
26. Precision cancer medicine: development and future- Prof. Maurie Markman
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31 min
27. Pediatric cancer testing- Prof. Joshua Schiffman
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27 min
28. Opposition to vaccination: a transatlantic discussion- Prof. Jonathan Temte
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26 min
29. Elective caesarean sections from an evolutionary perspective- Prof. Wenda Trevathan
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19 min
30. Antiphospholipid syndrome and Lupus- Prof. Graham Hughes
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16 min
31. Prescribing medications to children - a GP’s view- Dr. Amanda Simmons
Topics Covered
- Differentiation
- Early development
- Ex utero growth
- Gastrulation
- Mouse embryo
- Organogenesis
- Research
- Stem cells
- Transplantation
Biography
Born in Rama, an Arab Palestinian village in the Galilee region of Israel, Prof. Jacob (Yaqub) Hanna earned his BSc in medical science (2001), PhD in immunology (2007), and MD in clinical medicine summa cum laude (2007) from the Hebrew University of Jerusalem. He conducted postdoctoral research at the Whitehead Institute for Biomedical Research at MIT. He joined the department of Molecular Genetics at the Weizmann Institute in 2011.
Prof. Hanna is pioneering techniques in induced naïve pluripotency from adult cell and synthetic whole embryo models made solely from stem cells ex utero. Prof. Hanna was the lead researcher in a study that showed how further-modified iPS cells could be used to treat sickle-cell anemia in mice, the first proof of concept of the therapeutic application of iPS cells. He was the first to expand prolonged periods of advanced and normal mammalian embryo development from pre-gastrulation until late organogenesis in an “artificial uterus” environment outside the maternal womb. The latter platform enabled him to demonstrate the ability to be the first to generate advanced stage whole synthetic embryos made entirely from naïve pluripotent stem cells in the petri dish, that can complete gastrulation and demonstrate organ formation within adequate extra-embryonic compartments. In addition to demonstrating the power of cell reprogramming and ex utero synthetic advanced embryogenesis, his work offers the promise of powerful new research models for degenerative diseases, infertility, and modelling human early development.
During his postdoctoral work, Prof. Hanna received a prestigious Novartis Fellowship from the Helen Hay Whitney Foundation. In 2010, he was awarded the Sir Charles Clore Prize for Outstanding Appointment in the Weizmann Institute. He received an EMBO young investigator award (2012), a Rappaport Prize in biomedical research (2013), a Krill Prize by the Wolf Foundation (2013), and the Helen and Martin Kimmel Award for Innovative Investigation (2014). In 2014, he was featured among “40 under 40” innovative scientists by the prestigious journal Cell and was elected as a member of EMBO in 2018. In 2021, he ranked at the top of the list of 50 leading world thinkers by Prospect magazine.
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Talk Citation
Hanna, J.(. (2022, December 15). Synthetic whole embryo models and their applications [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/AKZC1162.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jacob (Yaqub) Hanna has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Audio Interview
Synthetic whole embryo models and their applications
Published on December 15, 2022
25 min
A selection of talks on Cell Biology
Transcript
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