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0:00
My name is Ying-Xian Pan.
I'm a Professor at the
Department of Anesthesiology,
Rutgers New Jersey
Medical School.
My research interests
have long focused
on the mechanism and the
function of opioid actions,
particularly as a route
to Mu opioid receptors.
Today, I will talk about
one of our stories,
how to translate our basic
science into the development of
normal opioid analgesics that are
potent, but lack side effects.
0:34
This slide shows drug overdose
deaths in the US in 2017.
About 70K overdoses
for all drugs
and about 47K for opioid
overdose deaths is more than
two-thirds of all
drug overdose deaths,
which also is the
driving force behind
this steep increase in the
death rate in recent years.
1:01
One main reason for
opioid overdose deaths is
opioid misuse through
either prescription
or illegal routes.
This slide shows that in 2017,
about 11 million people
misused opioids and
about 20 percent of the 2.1 million
people developed opioid use disorder.
However, the main reason for opioid
misuse is pain-over 62 percent.
What is pain?
1:34
The word pain comes from Latin,
Peona or Greek Poine,
meaning punishment or penalty.
Based on the International
Association for the Study of Pain,
pain is defined as an
unpleasant sensory
and emotional experience
associated with or
resembling that is
associated with
actual or potential
tissue damage
or described in terms
of such damage.
Pain is subjective
and protective, and
is modified by
developmental-behavioral,
personality, and
cultural factors.
Pain is the most common symptom
leading to physician contact.
Pain is the main reason for
opioid misuse contributing to
the worldwide opioid epidemic.
