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1. The deep history of life
- Prof. Andrew H. Knoll
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2. The neutral and nearly neutral theories of molecular evolution 2
- Prof. Joseph P. Bielawski
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3. The neutral and nearly neutral theories of molecular evolution 1
- Prof. Joseph P. Bielawski
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4. The coalescent
- Prof. Peter Beerli
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5. Evolution of drug resistance
- Dr. Pleuni Pennings
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6. Trends in macroevolution
- Prof. Luke Harmon
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7. Social evolution
- Prof. Dustin R. Rubenstein
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8. Principles of phylogeography and landscape genetics
- Dr. Ryan Garrick
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9. Evolutionary developmental biology
- Dr. Karen Sears
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10. Biogeography: explaining the geographical distribution of organisms
- Prof. Alexandre Antonelli
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11. Evolutionary case study: the genomics of speciation in Heliconius butterflies
- Prof. Adriana D. Briscoe
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12. Human evolution
- Prof. Vagheesh Narasimhan
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13. How do organisms evolve in response to global change?
- Prof. Erica Bree Rosenblum
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14. Conservation genomics: adaptation and gene flow
- Prof. Jacob Höglund
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15. Conservation genomics: genetic diversity and inbreeding
- Dr. Jacqueline Robinson
-
16. Evolution of agriculture: the origin of our food crops
- Dr. Mona Schreiber
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17. Evolutionary medicine
- Prof. Stephen C. Stearns
Printable Handouts
Navigable Slide Index
- Introduction
- The global extinction crisis
- Conservation: mission-driven and multidisciplinary
- Outline: aims and methods
- From genetics to genomics
- Aims of conservation genetics/genomics
- Data collection
- Scales of genetic diversity/biodiversity
- What do we look for in patterns of genetic diversity?
- Evolutionarily Significant Unit (ESU)
- Outline: applications based on genetics
- Four species of giraffe, not one
- Species (mis)identification
- Conservation forensics
- Environmental DNA (eDNA)
- Outline: genetic diversity and population size
- Quantifying genetic diversity
- Genetic diversity is correlated with population size
- Genetic diversity in islands vs. mainland populations
- Population bottlenecks and declines
- Genetic drift
- Effective population size
- Why is genetic diversity important?
- Loss of diversity in the endangered crested ibis
- Transmissible tumors in Tasmanian devils
- Inferring demographic history
- The complex history of dogs and wolves (1)
- The complex history of dogs and wolves (2)
- Outline: genomics of inbreeding and inbreeding depression
- Inbreeding
- Pedigrees
- Estimating F from a pedigree
- Runs of homozygosity
- Estimating F from genomic data
- Advantages of genomic data over pedigrees
- Extreme inbreeding in Isle Royale wolves
- Inbreeding depression
- Inbreeding may contribute to extinction
- Collapse of the Isle Roylae wolf population
- Deleterious variation in Isle Royale wolves
- Outline: preventing and reversing extinction
- Genetic rescue: a potential solution?
- Restoring lost diversity and de-extinction
- Genetic diversity does not predict extinction
- Summary
- Thank you
Topics Covered
- Aims and methods of conservation genetics
- Genetic similarity or distinctiveness
- Genetic diversity and population size
- Population bottlenecks
- Genetic drift
- Inbreeding and inbreeding depression
- Pedigrees vs. genetic data
- Preventing and reversing extinction
Links
Series:
Categories:
Talk Citation
Robinson, J. (2023, September 28). Conservation genomics: genetic diversity and inbreeding [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/YAGM4471.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Jacqueline Robinson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Plant & Animal Sciences
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, I'm Jacqueline
Robinson and I am
a postdoctoral researcher in
the Institute for
Human Genetics at
the University of
California, San Francisco.
In this presentation, we will be
covering some of the
fundamental theories and
practical applications
of conservation genomics
with a particular focus on
genetic diversity
and inbreeding.
0:22
There is accumulating
evidence that Earth is
currently in the midst of a
global extinction crisis,
driven by the direct and
indirect impacts
of human activity.
The five most prominent
factors driving
this extinction crisis are, one,
changes in land and sea use,
such as the draining of wetlands
or clearing of forests
for agriculture.
Two, the direct exploitation of
organisms such as
fishing and poaching.
Three, climate change.
Four, pollution, and
five, invasive species.
Unfortunately, as we see
in the graph on the left,
the extinction rates
of many groups
of organisms are
increasing rapidly.
Effective conservation
efforts are
needed now more than ever,
and will become increasingly
vital as time goes on.
1:08
Conservation is a
little different from
many other disciplines
in that it is mission
driven and highly
multidisciplinary.
Its ultimate mission
is to preserve
biodiversity and the
processes that sustain it.
Achieving this goal requires
incorporating many
fields of knowledge,
including ecology, evolution,
law, economics, and more.
In the rest of this presentation
we will be focusing
on how genetics factors
into conservation.
1:37
First, we will
cover the aims and
methods of modern
conservation genomics.
Then we will learn
about applications and
conservation based on
genetic similarity
or distinctiveness.
Then we will see how
genetic diversity
is correlated with
population size or
abundance before moving on to
the topics of inbreeding
and inbreeding depression.
Finally, we will see how
genomics may be useful in
efforts to prevent or
even reverse extinctions.