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Printable Handouts
Navigable Slide Index
- Introduction
- Metabolic syndrome and type 2 diabetes
- Evolution of man
- Visceral adiposity is not new
- Other possible causes of increased obesity
- Risk of obesity
- Effect of obesity
- Variability of VAT among obese subjects
- The "metabolic syndrome"
- Metabolic syndrome: a critical reappraisal
- "Metabolic xyndrome"
- Events in pathogenesis of metabolic xyndrome
- How the metabolic xyndrome occurs
- Animal models
- Visceral and subcutaneous adiposity
- Animals at basal sorted by body fat
- "Overflow hypothesis"
- Sequelae of IIFD (isocaloric higher fat)
- Adipocyte size distribution - control diet
- Adipocyte size distribution - high fat diet
- Isoproterenol stimulated lipolysis - high fat diet
- Liver temporal primacy in insulin resistance
- Gene expression and visceral adiposity
- Visceral fat depot
- Visceral lipolysis is pulsatile
- Effect of beta3-blockade on FFA release
- What causes increased FFA release?
- Flux of FFA to the liver
- High fat diet
- Liver histology
- Hepatic and peripheral insulin resistance
- Peripheral insulin resistance
- Effect of first-phase insulin
- Slow endothelial transport of insulin
- Setup
- Insulin concentration vs. glucose utilization rate
- Insulin sensitivity
- Distribution of insulin with obesity
- Transendothelial insulin transport (TET)
- The development of the metabolic xyndrome
- Cause of hyperinsulinemia
- Results of a high fat diet-fed animal model
- The signal for compensatory hyperinsulinemia
- What is the signal for beta-cell compensation?
- 24-hr plasma profiling
- 24-hr insulin
- Effect of 6 weeks of fat feeding
- Insulin, glucose, FFA nocturnal measurements
- Elevated overnight FFA following a high fat diet
- Pathogenesis of the metabolic xyndrome
Topics Covered
- Metabolic syndrome and type 2 diabetes
- Risk and effect of obesity
- "Metabolic syndrome"
- Pathogenesis of the metabolic syndrome
- Visceral and subcutaneous adiposity in the fat-fed dog model
- "Overflow" hypothesis
- Control diet and high fat diet
- Visceral adiposity
- Hepatic and peripheral insulin resistance
- Distribution of insulin with obesity
- Transendothelial insulin transport (TET)
- Hyperinsulinemia
- Insulin resistance
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Talk Citation
Bergman, R. (2007, December 1). Pathogenesis of the metabolic syndrome [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/VCWV1476.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Richard Bergman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.