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1. Introduction
2. Metabolic syndrome and type 2 diabetes
3. Evolution of man
4. Visceral adiposity is not new
5. Other possible causes of increased obesity
6. Risk of obesity
7. Effect of obesity
8. Variability of VAT among obese subjects
9. The "metabolic syndrome"
10. Metabolic syndrome: a critical reappraisal
11. "Metabolic xyndrome"
12. Events in pathogenesis of metabolic xyndrome
13. How the metabolic xyndrome occurs
14. Animal models
15. Visceral and subcutaneous adiposity
16. Animals at basal sorted by body fat
17. "Overflow hypothesis"
18. Sequelae of IIFD (isocaloric higher fat)
19. Adipocyte size distribution - control diet
20. Adipocyte size distribution - high fat diet
21. Isoproterenol stimulated lipolysis - high fat diet
22. Liver temporal primacy in insulin resistance
23. Gene expression and visceral adiposity
24. Visceral fat depot
25. Visceral lipolysis is pulsatile
26. Effect of beta3-blockade on FFA release
27. What causes increased FFA release?
28. Flux of FFA to the liver
29. High fat diet
30. Liver histology
31. Hepatic and peripheral insulin resistance
32. Peripheral insulin resistance
33. Effect of first-phase insulin
34. Slow endothelial transport of insulin
35. Setup
36. Insulin concentration vs. glucose utilization rate
37. Insulin sensitivity
38. Distribution of insulin with obesity
39. Transendothelial insulin transport (TET)
40. The development of the metabolic xyndrome
41. Cause of hyperinsulinemia
42. Results of a high fat diet-fed animal model
43. The signal for compensatory hyperinsulinemia
44. What is the signal for beta-cell compensation?
45. 24-hr plasma profiling
46. 24-hr insulin
47. Effect of 6 weeks of fat feeding
48. Insulin, glucose, FFA nocturnal measurements
49. Elevated overnight FFA following a high fat diet
50. Pathogenesis of the metabolic xyndrome

Topics Covered

• Metabolic syndrome and type 2 diabetes
• Risk and effect of obesity
• "Metabolic syndrome"
• Pathogenesis of the metabolic syndrome
• Visceral and subcutaneous adiposity in the fat-fed dog model
• "Overflow" hypothesis
• Control diet and high fat diet
• Visceral adiposity
• Hepatic and peripheral insulin resistance
• Distribution of insulin with obesity
• Transendothelial insulin transport (TET)
• Hyperinsulinemia
• Insulin resistance

Links

Series:

• The World of Hormones

Categories:

• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on December 1, 2007

Financial Disclosures

• Prof. Richard Bergman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.