• Introduction to the World of Hormones
• 45 min
  1. Introduction to hormones

  • Prof. Helen Henry
• The Reproductive Hormones
• 44 min
  2. Endocrinology of parturition

  • Dr. Errol Norwitz
• 54 min
  3. Menopausal hormone therapy

  • Prof. Hugh Taylor
• 53 min
  4. Understanding hormones: mechanisms of androgen receptor function in reproduction and cancer

  • Prof. Elizabeth Wilson
• Hormones in Calcium and Phosphorus Homeostasis
• 36 min
  5. Vitamin D endocrine system: basics

  • Prof. Anthony Norman
• 47 min
  6. Vitamin D endocrine system: mechanisms to produce biological responses

  • Prof. Anthony Norman
• 37 min
  7. Parathyroid hormone and parathyroid hormone-related protein

  • Prof. Robert Nissenson
• 51 min
  8. Hormonal influence on bone remodeling and its implications for the pathophysiology of osteoporosis

  • Prof. Stavros Manolagas
• Hormones and the Vasculature
• 52 min
  9. Vascular cell signaling by membrane estrogen receptors

  • Prof. Jeffrey Bender
• Hormones and Energy Metabolism
• 41 min
  10. Pathogenesis of the metabolic syndrome

  • Prof. Richard Bergman
• Hormones and Growth
• 31 min
  11. The growth hormone/insulin-like growth factor-1 axis in health and disease

  • Prof. Derek LeRoith
• Frontiers in Hormone Research
• 47 min
  12. Prevention of type 1 diabetes

  • Prof. Chantal Mathieu
• 27 min
  13. Actions of steroid hormones in the brain

  • Prof. Bruce McEwen
• 40 min
  14. Vitamin D and prostate cancer

  • Prof. David Feldman
• Archived Lectures *These may not cover the latest advances in the field
• 46 min
  15. G-protein coupled receptors: hormone membrane receptors

  • Prof. Stuart Sealfon
• 40 min
  16. Nuclear receptors: transcriptional functions

  • Prof. Nancy Weigel
  • Dr. Neil McKenna
• 60 min
  17. Steroid hormones and their receptors in breast cancer

  • Prof. JoEllen Welsh
• 44 min
  18. Nuclear receptor superfamily: structural insights into function

  • Prof. Dino Moras
• 53 min
  19. Receptor tyrosine kinases - function, families and evolution

  • Prof. Tony Hunter
• 58 min
  20. Can we prevent type I diabetes?

  • Prof. Chantal Mathieu
• 39 min
  21. Vitamin D endocrine system: VDR binding, nutrition and drugs development

  • Prof. Anthony Norman

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Rhodopsin: prototype GPCR
3. Major classes of GPCRs
4. Class I: rhodopsin-like
5. Class II: glucagon-like
6. Class III: mGlu-like
7. Experimental approaches to study GPCR structure
8. Rhodopsin crystal structure
9. Post-translational modifications
10. Mechanisms of ligand interaction
11. Rhodopsin
12. Neurotransmitter binding
13. Peptide hormone: receptor complexing
14. Glycoprotein hormone receptors
15. GPCR activation
16. Terniary and extended terniary model
17. Rigid body model
18. Rigid body model: ESR evidence
19. SJ receptor
20. Coupling promiscuity
21. Signal trafficking
22. Agonist-directed signaling - role in drug specificity
23. Involvement of non-G protein signaling
24. Mechanism of hallucinogens
25. Receptor RNA processing/isoforms
26. RNA editing
27. GRKs/arrestin
28. Arrestin-dependent internalizaton
29. Non-heterotrimeric G protein coupling
30. Dimerization
31. Rhodopsin dimerization
32. Functional D2R SSTR5 dimer
33. RAMPs (receptor activity modifying protein)
34. Biological functions for RAMPs
35. RAMPs, heterodimers and expression
36. GPCRs and disease
37. Thyroxine and thyrotropin during pregnancy
38. cAMP production in WT and mutants
39. Suggestions for further reading, acknowledgments

Topics Covered

• Rhodopsin: prototype GPCR
• Major classes of GPCRs: rhodopsin-like, glucagon-like, mGlu-like
• Experimental approaches to study GPCR structure
• Rhodopsin crystal structure
• GPCR activation
• Signal trafficking
• Receptor RNA processing/isoforms
• GRKs/arrestin
• Rhodopsin dimerization
• RAMPs: receptor activity modifying protein
• RAMPs, heterodimers and expression
• GPCRs and disease
• Thyroxine and thyrotropin

Links

Series:

• The World of Hormones

Categories:

• Biochemistry

Talk Citation

Publication History

• Published on December 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Stuart Sealfon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.