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1. Introduction
2. Transcription factors (TFs)
3. Ligands of nuclear receptors
4. Receptor-DNA binding and hormones
5. Protein recruitment and hormones
6. Classes of nuclear receptors
7. Ligand structures: type I nuclear receptors
8. Type I receptor antagonists
9. Ligand structures: type II nuclear receptors
10. The nuclear receptor superfamily
11. Steroid receptors share 3 regions of homology
12. Receptor isoforms regulate hormone response
13. Isoforms of the human progesterone receptor
14. Isoforms of the human glucocorticoid receptor
15. DNA-binding domain homology
16. Homology domains contain two zinc fingers
17. Receptors' P-boxes and half-site binding sites
18. Receptors binding a palindromic half site
19. Receptors binding a direct repeat half site
20. The hormone binding domain (1)
21. The hormone binding domain (2)
22. Role of helix 12 in the estrogen receptor alpha
23. Steroid receptor action
24. Where are unliganded steroid receptors?
25. Role of receptor-heat shock proteins complex
26. Protein recruitment and chromatin modification
27. Coregulators of the nuclear receptor
28. Identification of interacting proteins
29. SRC/p160 coactivator family
30. Nuclear receptor interaction motifs
31. SRC/p160 coactivator family - the NR box
32. Histone acetylation and chromatin structure
33. Coactivators: proteins with diverse activities
34. Nuclear Receptor Signaling Atlas (NURSA)
35. Chromatin immunoprecipitation assay (1)
36. Chromatin immunoprecipitation assay (2)
37. Chromatin immunoprecipitation assay (3)
38. Chromatin immunoprecipitation assay (4)
39. Location of hormone response elements
40. Type II nuclear receptors: mechanisms of action
41. The thyroid hormone receptor
42. The coregulator exchange
43. Corepressors and type I nuclear receptors
44. Independent transcriptional activation by NRs
45. Repression of IL-8 expression
46. Transrepression by activated nuclear receptors
47. NRs regulate transcription by kinase activation
48. Summary: steroid receptor action

Topics Covered

• Introduction to transcription factors
• Nuclear receptors as ligand-dependent transcription factors
• Classes of nuclear receptor
• Nuclear receptor ligands: agonists and antagonists
• Nuclear receptor phylogeny
• Nuclear receptor isoforms
• The nuclear receptor DNA-binding domain
• Hormone response elements
• The nuclear receptor ligand-binding domain
• Nuclear receptor mechanism
• Subcellular localization of nuclear receptors
• The effect of ligand binding
• Nuclear receptor coregulators
• Initial discoveries of coregulators
• The SRC/p160 coregulator family
• Nuclear receptor-coregulator interaction motifs
• Histone acetylation and chromatin structure
• The Nuclear Receptor Signaling Atlas (NURSA)
• Chromatin immunoprecipitation as a tool in nuclear receptor mechanism
• Functional differences between type I and type II nuclear receptors
• The coregulator exchange
• DNA-binding independent functions
• Transrepression
• The role of kinases

Links

Series:

• The World of Hormones

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Weigel, N. and McKenna, N. (2007, December 1). Nuclear receptors: transcriptional functions [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 17, 2025, from https://doi.org/10.69645/PGPK8119.
Export Citation (RIS)

Publication History

• Published on December 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Nancy Weigel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Neil McKenna has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.