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Printable Handouts
Navigable Slide Index
- Introduction
- 48 nuclear receptors in human - many orphans
- Signal transduction and transcriptional regulation
- Cofactor binding and transcriptional activation
- The modular organization of NHRs
- The DNA binding domain (DBD)
- Response elements
- The canonical fold of LBDs
- LBD: the oligomeric state
- ER-alpha bound to estradiol
- PR and AR bound to their ligands
- RXR-alpha - RAR-alpha
- NGFI-B
- Structure of NR bound to DNA
- Multiple alignments
- Sequence/structure to function
- Dimerization and communication pathways in NRs
- Closer view of RXR and RAR
- LBD: allosteric control
- Communication pathway in NRs
- Allosteric control of hRAR-alpha phosphorylation
- LBD: ligand binding
- Plasticity of the LBD
- The retinoids receptors
- Mouse trap model
- Several conformational states of RXR
- RAR and its activating ligands
- Mutual adaptation of RAR, RXR and their ligands
- Structural adaptability of the ecdysone receptor
- Ecdysone receptor EcR/ ultraspiracle protein USP
- PonA and natural and synthetic ligands
- LBD: binding to cofactors
- Signature motif
- Cofactor binding and transcriptional activation
- The LBD with a bound coactivator peptide
- LBD: ligand dependent (de)activation
- Estrogen receptor-drug interactions
- Apo-agonist-antagonist
- Structural studies on LBD of ERR-gamma
- ERR3 ligand binding pocket
- Mechanism of ERR-gamma inactivation by DES
- The vitamin D receptor (VDR)
- Crystal structure of the VDR LBD
- Mutations of VDR LBD found in rickets syndrome
- Synthetic vitamin D analogs (20-epi compounds)
- Ligands adapt to the VDR ligand-binding pocket
- The presence of water channles
- VDR's ligand binding pocket and 'Gemini' analog
- Conclusion
Topics Covered
- Signal transduction and transcriptional regulation
- Cofactor binding and transcriptional activation
- The modular organization of nuclear hormone receptors
- The DNA binding domain
- The ligand binding domain
- Sequence/structure to function
- The oligomeric state
- Allosteric control through post-translational modifications
- Communication pathways in NRs
- Ligand binding: specificity and adaptability
- The retinoid receptors: RXR and RAR
- Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
- Binding to coactivators and corepressors: the signature motifs
- Ligand dependent (de)activation: agonists and antagonists
- Estrogen receptor
- The vitamin D receptor
Talk Citation
Moras, D. (2007, December 1). Nuclear receptor superfamily: structural insights into function [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/YDOQ6378.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Dino Moras has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.