• Introduction to Genetic Diversity
• 72 min
  1. The sources of genomic diversity

  • Dr. George Nelson
• 27 min
  2. Bioinformatics tools in conservation biology

  • Dr. Mahmood Shivji
  • Mr. Vincent Richards
• Populations, Samples and Biological Databases
• 48 min
  3. Specimen banking: saving for the future

  • Ms. Elaine Gunter
• Bioinformatics and Genome Analysis
• 44 min
  4. Accessing and using ENCODE data

  • Prof. Peggy Farnham
• 47 min
  5. Information content in sequences and its relation to protein structure prediction

  • Dr. Rosemarie Swanson
• 40 min
  6. Pattern discovery in bioinformatics

  • Prof. Giri Narasimhan
• Human Disease
• 38 min
  7. Genes in common diseases

  • Prof. Jennie Lou
• 42 min
  8. The impact of genomic architecture and diversity on infectious diseases

  • Prof. Vincent Chow
  • Dr. Meena Sakharkar
• 29 min
  9. The predominant clonal evolution (PCE) concept of microbial pathogens and its practical usefulness

  • Dr. Michel Tibayrenc
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  10. Unity and diversity in microbial genomes

  • Dr. Kishore Sakharkar
• 38 min
  11. Analysis of protein-protein interaction, transcriptional regulation and metabolic networks

  • Dr. Andreas Wagner
• 39 min
  12. Exploring and predicting phenotype and function in cancer biology: working in high dimensional data spaces

  • Prof. Robert Clarke
• 59 min
  13. Widespread structural variations in the human genome

  • Dr. Charles Lee
• 39 min
  14. Human genome variation

  • Dr. Kelly Frazer
• 36 min
  15. Human genetic variation and therapeutic development

  • Dr. Sally John
  • Dr. Nick Davies
• 62 min
  16. Evolving genomic approaches to the study of complex cardiovascular diseases in human populations: genetic and genomic epidemiology

  • Dr. Christopher O'Donnell
• 42 min
  17. Population genetics studies in Africa: curiosity and challenges

  • Prof. Himla Soodyall
• 37 min
  18. Sample collection for human genetics

  • Dr. Michael Dean
• 40 min
  19. Diagnosis of early relapse in ovarian cancer using serum proteomic profiling

  • Dr. Jean Gao

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Phenotypic differences
3. DNA polymorphisms
4. Single nucleotide polymorphisms - SNPs
5. Questions to be discussed
6. Correlation structure of common SNPs
7. Human whole-genome high-density arrays
8. Amplifying the human genome
9. Detection of DNA variation
10. SNP markers across the genome
11. Relationships between common SNPs
12. Experimental design
13. Characterisitics of 1.6 million SNPs
14. Linkage disequilibrium - LD
15. LD bin structure of the CFTR gene
16. Most SNPs are in LD bins
17. HapMap phase II
18. Summary
19. Deletion polymorphisms
20. Intermediate deletions
21. Experimental design
22. Identification of intermediate deletions
23. Percent conformance
24. Intermediate deletion polymorphisms in humans
25. Some deletions are rare
26. Some deletions are common
27. Some deletions may have functional consequences
28. Summary of results
29. Frequency spectrum for intermediate deletions
30. Allele frequency spectrum
31. Intermediate deletions in 3 genotyped populations
32. LD patterns (1)
33. LD patterns (2)
34. Summary
35. Acknowledgements

Topics Covered

• DNA polymorphisms in the human genome
• Identification of a large number of common Single Nucleotide Polymorphisms (SNPs)
• The relationship of these common SNPs in linkage disequilibrium bins
• The majority of common deletion polymorphisms in humans are in linkage disequilibrium with common SNPs

Links

Series:

• Using Bioinformatics in the Exploration of Genetic Diversity

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Kelly Frazer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.