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Navigable Slide Index

1. Introduction
2. Phenotypic differences
3. DNA polymorphisms
4. Single nucleotide polymorphisms - SNPs
5. Questions to be discussed
6. Correlation structure of common SNPs
7. Human whole-genome high-density arrays
8. Amplifying the human genome
9. Detection of DNA variation
10. SNP markers across the genome
11. Relationships between common SNPs
12. Experimental design
13. Characterisitics of 1.6 million SNPs
14. Linkage disequilibrium - LD
15. LD bin structure of the CFTR gene
16. Most SNPs are in LD bins
17. HapMap phase II
18. Summary
19. Deletion polymorphisms
20. Intermediate deletions
21. Experimental design
22. Identification of intermediate deletions
23. Percent conformance
24. Intermediate deletion polymorphisms in humans
25. Some deletions are rare
26. Some deletions are common
27. Some deletions may have functional consequences
28. Summary of results
29. Frequency spectrum for intermediate deletions
30. Allele frequency spectrum
31. Intermediate deletions in 3 genotyped populations
32. LD patterns (1)
33. LD patterns (2)
34. Summary
35. Acknowledgements

Topics Covered

• DNA polymorphisms in the human genome
• Identification of a large number of common Single Nucleotide Polymorphisms (SNPs)
• The relationship of these common SNPs in linkage disequilibrium bins
• The majority of common deletion polymorphisms in humans are in linkage disequilibrium with common SNPs

Links

Series:

• Using Bioinformatics in the Exploration of Genetic Diversity

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Kelly Frazer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.