• Introduction to Genetic Diversity
• 27 min
  1. Bioinformatics tools in conservation biology

  • Dr. Mahmood Shivji
  • Mr. Vincent Richards
• Populations, Samples and Biological Databases
• 48 min
  2. Specimen banking: saving for the future

  • Ms. Elaine Gunter
• Human Disease
• 42 min
  3. The impact of genomic architecture and diversity on infectious diseases

  • Prof. Vincent Chow
  • Dr. Meena Sakharkar
• 29 min
  4. The predominant clonal evolution (PCE) concept of microbial pathogens and its practical usefulness

  • Dr. Michel Tibayrenc
• Archived Lectures *These may not cover the latest advances in the field
• 29 min
  5. Unity and diversity in microbial genomes

  • Dr. Kishore Sakharkar
• 38 min
  6. Analysis of protein-protein interaction, transcriptional regulation and metabolic networks

  • Dr. Andreas Wagner
• 39 min
  7. Exploring and predicting phenotype and function in cancer biology: working in high dimensional data spaces

  • Prof. Robert Clarke
• 59 min
  8. Widespread structural variations in the human genome

  • Dr. Charles Lee
• 39 min
  9. Human genome variation

  • Dr. Kelly Frazer
• 36 min
  10. Human genetic variation and therapeutic development

  • Dr. Sally John
  • Dr. Nick Davies
• 62 min
  11. Evolving genomic approaches to the study of complex cardiovascular diseases in human populations: genetic and genomic epidemiology

  • Dr. Christopher O'Donnell
• 42 min
  12. Population genetics studies in Africa: curiosity and challenges

  • Prof. Himla Soodyall
• 37 min
  13. Sample collection for human genetics

  • Dr. Michael Dean
• 40 min
  14. Diagnosis of early relapse in ovarian cancer using serum proteomic profiling

  • Dr. Jean Gao
• 47 min
  15. Information content in sequences and its relation to protein structure prediction

  • Dr. Rosemarie Swanson
• 72 min
  16. The sources of genomic diversity

  • Dr. George Nelson
• 44 min
  17. Accessing and using ENCODE data

  • Prof. Peggy Farnham
• 40 min
  18. Pattern discovery in bioinformatics

  • Prof. Giri Narasimhan
• 38 min
  19. Genes in common diseases

  • Prof. Jennie Lou

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Microbes everywhere
3. Different shapes of bacteria
4. Different sizes of bacteria
5. Genome data
6. Microbial genome sequencing
7. Microbial evolutionary genomics
8. Bacterial lifestyles
9. Topics
10. Genome size and number of genes
11. Minimal genome
12. Gene order comparison
13. Gene order in microbial genomes
14. Conservation of gene order in bacterial species
15. Mycoplasma species and gene order
16. Gene order conservation in closely related genera
17. Lack of gene order conservation
18. Protein length profile
19. PPD - proteome profile database
20. Obligatory genomes and associated diseases
21. Parasites possess small genomes
22. Genome compaction
23. Problems
24. Protein length distribution
25. Backbone genome and gene loss
26. More genomes and backbone genome
27. Different COG
28. COG category distribution
29. Common themes
30. Overlapping Genes (1)
31. Overlapping Genes (2)
32. Directions of overlap
33. Overlapping genes in nine genomes
34. Which genes overlap
35. Conclusion
36. Thank you

Topics Covered

• Host-pathogen interaction
• Microbial genomics
• Properties and functions of microbes: their genomes, protein coding, sequences and putative biochemical pathways
• The concept of the "universal" minimal genome
• Strategies used by obligatory intracellular parasites for genome reduction and survival
• The use of comparative genomics in understanding the concept of the "backbone genome"
• Differential gene loss and overlapping genes
• Drug targets

Links

Series:

• Using Bioinformatics in the Exploration of Genetic Diversity

Categories:

• Genetics & Epigenetics
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Kishore Sakharkar has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.