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- Introduction to Genetic Diversity
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72 min
1. The sources of genomic diversity- Dr. George Nelson
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27 min
2. Bioinformatics tools in conservation biology- Dr. Mahmood Shivji
- Mr. Vincent Richards
- Populations, Samples and Biological Databases
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48 min
3. Specimen banking: saving for the future- Ms. Elaine Gunter
- Bioinformatics and Genome Analysis
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44 min
4. Accessing and using ENCODE data- Prof. Peggy Farnham
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47 min
5. Information content in sequences and its relation to protein structure prediction- Dr. Rosemarie Swanson
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40 min
6. Pattern discovery in bioinformatics- Prof. Giri Narasimhan
- Human Disease
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38 min
7. Genes in common diseases- Prof. Jennie Lou
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42 min
8. The impact of genomic architecture and diversity on infectious diseases- Prof. Vincent Chow
- Dr. Meena Sakharkar
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29 min
- Archived Lectures *These may not cover the latest advances in the field
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29 min
10. Unity and diversity in microbial genomes- Dr. Kishore Sakharkar
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38 min
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39 min
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59 min
13. Widespread structural variations in the human genome- Dr. Charles Lee
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39 min
14. Human genome variation- Dr. Kelly Frazer
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36 min
15. Human genetic variation and therapeutic development- Dr. Sally John
- Dr. Nick Davies
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62 min
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42 min
17. Population genetics studies in Africa: curiosity and challenges- Prof. Himla Soodyall
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37 min
18. Sample collection for human genetics- Dr. Michael Dean
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40 min
Printable Handouts
Navigable Slide Index
- Introduction
- Microbes everywhere
- Different shapes of bacteria
- Different sizes of bacteria
- Genome data
- Microbial genome sequencing
- Microbial evolutionary genomics
- Bacterial lifestyles
- Topics
- Genome size and number of genes
- Minimal genome
- Gene order comparison
- Gene order in microbial genomes
- Conservation of gene order in bacterial species
- Mycoplasma species and gene order
- Gene order conservation in closely related genera
- Lack of gene order conservation
- Protein length profile
- PPD - proteome profile database
- Obligatory genomes and associated diseases
- Parasites possess small genomes
- Genome compaction
- Problems
- Protein length distribution
- Backbone genome and gene loss
- More genomes and backbone genome
- Different COG
- COG category distribution
- Common themes
- Overlapping Genes (1)
- Overlapping Genes (2)
- Directions of overlap
- Overlapping genes in nine genomes
- Which genes overlap
- Conclusion
- Thank you
Topics Covered
- Host-pathogen interaction
- Microbial genomics
- Properties and functions of microbes: their genomes, protein coding, sequences and putative biochemical pathways
- The concept of the "universal" minimal genome
- Strategies used by obligatory intracellular parasites for genome reduction and survival
- The use of comparative genomics in understanding the concept of the "backbone genome"
- Differential gene loss and overlapping genes
- Drug targets
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Sakharkar, K. (2007, October 1). Unity and diversity in microbial genomes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 21, 2025, from https://doi.org/10.69645/UNLQ3460.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Kishore Sakharkar has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
