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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- What is nuclear medicine?
- Other diagnostic modalities
- Comparison of modalities
- Frequency of use
- Hybrid imaging
- Nuclear medicine is different: radiopharmaceutical
- Nuclear medicine is a multidisciplinary speciality
- Outline: radiation and detection
- Types of radioactive emissions
- Comparison of emissions
- Frequencies of uses
- Types of cameras
- Planar gamma scintigraphy
- SPECT
- Dual-headed gamma camera for SPECT
- Basis of PET
- PET-CT scanner
- Outline: radiopharmaceuticals
- Production of radionuclides
- Most common radionuclides
- Production of radiopharmaceuticals
- Challenges in preparation of radiopharmaceuticals
- Meeting the challenges
- Two parts of a radiopharmaceutical
- Theranostics
- Localisation mechanisms
- Technetium-99m (99mTc)
- Outline: diagnostic: gamma/SPECT
- International differences
- Bone scan
- Bone scan examples
- Myocardial perfusion imaging
- Ischemia vs. infarct
- Stress vs. rest studies
- Prognostic value
- Sentinel lymph node concept
- Surgery for cancer
- Dilemma
- Sentinel node approach
- Sentinel node procedure
- Impact of sentinel node
- Outline: clinical use - PET
- 18F-fluorodeoxyglucose (FDG)
- Mechanism of action
- FDG PET/CT in staging of lymphoma
- Impact of FDG PET
- Impact - continued
- Imaging of dementia
- AD: progression
- Development of tracers
- Comparison of PET amyloid agents
- Problems
- Neurochemical phases of AD
- Outline: therapeutic
- Principles of targeted therapy
- Types of radioactive emissions
- Pros and cons
- Thyroid disease
- Thyroid uptake of radioiodine
- Successful treatment of nodule
- Treatment of thyroid cancer
- Evolution of 131I therapy
- Neuroectodermal tumours
- Administration of 131I-MIBG
- Recent advances with 131I-MIBG
- Palliation of bone metastases
- Radionuclides for bone therapy
- Radium-223
- Phase II: survival curves with 223Ra
- 223Ra (Xofigo®, Bayer)
- Somatostatin analogues
- Imaging to therapy
- Impact of licensing 223Ra and 177Lu-DOTATATE
- Prostate-specific membrane antigen
- Outline: summary and future directions
- Summary
- Future directions
Topics Covered
- What is nuclear medicine?
- Radiopharmaceuticals
- Radiation and detection
- Theranostics
- Clinical uses of SPECT
- Clinical uses of PET
- The future of nuclear medicine
Talk Citation
Ballinger, J.R. (2021, July 28). An introduction to nuclear medicine [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/MHBY9701.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. James R. Ballinger has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Methods
Transcript
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0:00
Hello, my name is James Ballinger and I'm a retired senior lecturer
from King's College London, Division of Imaging Sciences.
The title of today's talk is 'An Introduction to Nuclear Medicine'.
Nuclear medicine is generally classified as a modality of diagnostic imaging,
although it also has some therapeutic applications, as we'll be seeing.
I've been in the field for about 40 years, half of that in Canada, and more recently in Britain.
During that time there have been great advances in the field, which are continuing
today, and I'll be talking about some of the most recent advances towards the end of the talk.
0:41
I'll begin by defining nuclear medicine, showing how it relates to the other diagnostic imaging modalities.
Then I'll talk about the radiations, types of radiation that are used, and how they're detected.
Moving on to what makes nuclear medicine different, the radiopharmaceutical,
how these are produced and designed to localise in different organ systems.
The bulk of the talk will be about clinical uses, and of those
mainly the diagnostic, with two different modalities that I'll be defining in a moment.
Then there are therapeutic applications, and I'll finish off with a summary and some future directions.
1:19
Nuclear medicine is a non-invasive diagnostic tool, part of
imaging sciences or medical imaging in most hospitals, sometimes a radiology department,
sometimes other specialties, but it provides functional rather than purely structural information.
It's sometimes called (in recent years) 'molecular imaging',
you're imaging molecules in the body.
In many conditions it can be extremely sensitive and specific,
but it often requires additional information,
such as the patient's clinical history, results from blood tests and so on, and other imaging modalities.