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- Function of important examples of PTK receptor families
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1. The molecular basis of insulin action
- Prof. Morris White
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2. The Eph receptor family
- Prof. Elena Pasquale
- Structure of PTK receptors and regulation of their kinases
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3. EGF receptor family: targets for improving cancer therapy
- Prof. Tony Burgess
- Intracellular signal transduction by PTK receptors
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4. PI 3-kinases and lipid messengers
- Prof. Bart Vanhaesebroeck
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5. RTKs activate the ERK 1/2 MAPK cascade
- Prof. Melanie H. Cobb
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6. The ERK1/2 MAPK cascade
- Prof. Melanie H. Cobb
- Archived Lectures *These may not cover the latest advances in the field
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7. Receptor tyrosine kinases - function, families and evolution
- Prof. Tony Hunter
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9. How the PDGF receptor induces cell proliferation
- Dr. Andrius Kazlauskas
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10. VEGF inhibitors for anti-angiogenic therapy
- Prof. Kari Alitalo
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12. Activation of PTK receptors in solid human tumors
- Dr. Marco Pierotti
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14. SH2-containing PTPs (Shps) in RTK signaling and disease
- Prof. Benjamin G. Neel
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16. Phospholipase C Gamma
- Prof. Graham Carpenter
- Ms. Cornelia Crooke
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17. Imatinib as a paradigm of targeted cancer therapies
- Prof. Brian Druker
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18. EGFR targeted therapies in lung cancer
- Dr. Pasi Janne
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19. The VEGF family
- Prof. Kari Alitalo
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20. The HGF receptor, a targettable regulator of invasive growth
- Prof. Paolo Comoglio
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21. Structural biology of FGF signaling in human development and disease
- Dr. Moosa Mohammadi
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22. EGF receptor family: targets for cancer therapeutics
- Prof. Tony Burgess
Printable Handouts
Navigable Slide Index
- Introduction
- Receptor tyrosine kinases
- Signal transduction pathways
- PLC-gamma
- PLC-gamma is an PIP2-specific hydrolytic enzyme
- What is PIP2?
- What is DAG?
- Diacylglycerol production
- What is IP3 ?
- How is PLC-gamma activated?
- The PI-specific PLC family
- What defines a phospholipase C?
- Domains in PLC-gamma 1
- Association of PLC-gamma 1 with the receptor
- PLC-gamma 1 association with the membrane
- Tyrosine phosphorylation of PLC-gamma 1
- PLC-gamma 1 Verses PLC-gamma 2
- Measurement of PLC-gamma 1
- Measurement of PLC-gamma tyrosine phosphorylation
- In vivo measurement of IP3
- In vivo measurement of intracellular Ca2+ release
- Measurement of PLC-gamma 1 activity in vitro
- T-Cell proliferation
- Role of immediate early genes in cell proliferation
- Downstream effects of PLC signaling
- Role of PLC-gamma in IL-2 expression
- T-cell receptor activation
- TK phosphorylation of PLC-gamma 1 in T-cells
- Calcium regulation of IL-2 transcription
- DAG control of IL-2 transcription (1)
- DAG control of IL-2 transcription (2)
- Role of PLC-gamma in IL-2 expression
- Cell morphogenesis
- Role of integrins in cell morphogenesis
- Role of PLC-gamma 1 in cell morphogenesis
- PLC-gamma biologic roles
Topics Covered
- PLC-gamma in growth factor signaling
- PLC-gamma as an enzyme
- Substrate and products
- PLC family members
- Domains
- Association of PLC-gamma with activated receptor tyrosine kinases and membranes
- Tyrosine phosphorylation sites of PLC-gamma
- PLC-gamma1 verses PLC-gamma2
- Measurement of protein and enzymatic activation
- Downstream signaling by PLC-gamma in T cells
- PLC-gamma mediation of integrins during adhesion and spreading
- PLC-gamma biologic roles
Talk Citation
Carpenter, G. and Crooke, C. (2007, October 1). Phospholipase C Gamma [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 27, 2024, from https://hstalks.com/bs/463/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Graham Carpenter has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Ms. Cornelia Crooke has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.