Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Tyrosine phosphorylation
3. The tyrosine phosphatase superfamily (HCx5R)
4. The classical PTP family (HCSxGxGRxG)
5. Goals
6. Shps: a brief historical review
7. Shps: similarities and differences
8. Shp structure, enzymology and regulation
9. Primary structure of Shps
10. Role of the SH2 domains
11. PTP catalytic mechanism
12. Substrate trapping mutants
13. Shps are regulated by their SH2 domains
14. Crystal structure of the N-terminal of Shp2 (1)
15. PTP/N-SH2 interface (open book)
16. Crystal structure of the N-terminal of Shp2 (2)
17. Regulation of Shp2 activity
18. Other regulatory mechanisms (1)
19. Other regulatory mechanisms (2)
20. Physiological functions of Shps
21. Previous Shp2 mutant mice
22. Shp2 "null" mice
23. Shp1 deficiency causes the Motheaten phenotype
24. Shp2: role in RTK signaling
25. Shp2 regulation of Ras-ERK pathway (1)
26. Shp2 regulation of Ras-ERK pathway (2)
27. Shp2 regulation of Ras-ERK pathway (3)
28. Regulation of other pathways by Shp2
29. Shp1: role in RTK signaling
30. Shps in disease
31. Noonan syndrome (NS): common human disorder
32. Shp2 mutations and leukemia
33. Juvenile myelomonocytic leukemia (JMML)
34. Shp2 mutations in NS and leukemia
35. Most disease-associated mutants map to interface
36. Activated mutants cause NS and leukemia
37. Shp2 mutant enzymology: summary
38. NS mutants: signaling effects
39. RTK pathways potentially perturbed in NS
40. Shp2 mutants and leukemia
41. Variations on the theme of activated mutants (1)
42. Variations on the theme of activated mutants (2)
43. Not all Shp2 mutants act as activated mutants
44. LEOPARD syndrome (LS): Shp2 mutations
45. LS mutants map to residues involved in catalysis
46. LS mutants: enzymology and signaling effects
47. Shps: key questions and challenges

Topics Covered

• Introduction to the PTP superfamily
• Shps, history and overview
• Shp stucture: role of SH2 domains, PTP domains, C-tail
• catalytic mechanism
• Regulation by phosphotyrosyl peptides, phosphorylation, reactive oxygen species
• Overview of physiological functions
• Role in RTK signaling: regulation of Ras/Erk pathway; roles in other downstream cascades
• Shps in disease
• Key questions and challenges for the future

Links

Series:

• Signal Transduction via Protein Tyrosine Kinase Receptors

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Neel, B.G. (2007, October 1). SH2-containing PTPs (Shps) in RTK signaling and disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/WBML3891.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Benjamin G. Neel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.