• Cancer and Oncology
• 30 min
  1. The molecular basis of cancer metastasis: molecular mechanisms of epithelial-mesenchymal transition in tumor metastasis

  • Prof. Jing Yang
• 26 min
  2. The molecular basis of cancer metastasis: multi-step metastasis process and anti-metastasis therapeutic development

  • Prof. Jing Yang
• 28 min
  3. Latest advances in the development of CAR & TCR T-cell treatments for solid tumours

  • Dr. Else Marit Inderberg
• 36 min
  4. Mode of action of T cells engineered with CAR or TCR for cancer treatment

  • Prof. Sebastian Kobold
• 37 min
  5. Immunotherapy: insights from advanced disease

  • Dr. Sara M. Tolaney
• 35 min
  6. Recent advances in the field of non-coding RNAs in cancer

  • Prof. George Calin
  • Dr. Maitri Shah
• 34 min
  7. How tumor-microenvironment interactions drive or inhibit metastasis

  • Prof. Isaac P. Witz
• 23 min
  8. A novel cancer therapy to stimulate oncogenic ERK signalling

  • Prof. Reiko Sugiura
• 37 min
  9. MRD-driven multiple myeloma treatment: next step forward

  • Prof. Ola Landgren
• 34 min
  10. The role of exosomes in multiple myeloma development & drug resistance

  • Prof. Eline Menu
• 29 min
  11. Germinal centre lymphomas: advances in diagnostic and therapeutic intervention

  • Dr. Koorosh Korfi
  • Prof. Jude Fitzgibbon
• 37 min
  12. Immunotherapy in lung cancer

  • Dr. Mark M. Awad
• 35 min
  13. Preservation of fertility in cancer patients: the impact of chemotherapy

  • Prof. Kutluk H. Oktay
• 41 min
  14. Preservation of fertility in cancer patients: BRCA mutations, ovarian tissue cryopreservation and transplantation, and pharmacological treatments in fertility preservation

  • Prof. Kutluk H. Oktay
• 47 min
  15. Solution proposed to a 2000 year old problem in oncology

  • Dr. Michael Retsky
• Clinical Practice
• 36 min
  16. Stillbirth: diagnosis, investigation and aftercare

  • Prof. Alexander E. P. Heazell
• 30 min
  17. Analyzing the medical relevance of skin care trends

  • Prof. Zoe Draelos
• 42 min
  18. Genetic counseling: preconception, prenatal, perinatal

  • Prof. Aubrey Milunsky
• 26 min
  19. The past, present & future of ANA testing: history and challenges of ANA

  • Prof. Marvin J. Fritzler
• 33 min
  20. The past, present & future of ANA testing: changing bandwidth and future of ANA

  • Prof. Marvin J. Fritzler
• 40 min
  21. Modern management of rheumatoid arthritis - with a focus on biologic therapies

  • Prof. John Isaacs
• 33 min
  22. Mitochondrial diseases: an update

  • Dr. Ayesha Saleem
• 31 min
  23. Hemophilia A

  • Dr. Snejana Krassova
• 32 min
  24. Artificial intelligence in medicine: history & state of the art

  • Prof. John Fox
• 27 min
  25. Artificial intelligence in medicine: scaling & deployment of applications

  • Prof. John Fox
• 36 min
  26. Recent advances in diagnosis and interventions in ophthalmology

  • Dr. Rebecca Kaye
  • Prof. Andrew Lotery
• Gastroenterology
• 34 min
  27. Building implantable human liver tissue from pluripotent stem cells

  • Prof. David C. Hay
• 35 min
  28. Microbiome therapies to treat gastrointestinal diseases

  • Dr. Patricia Bloom
• 46 min
  29. Drug-induced liver injury: importance, epidemiology, and mechanisms of DILI

  • Prof. James H. Lewis
• 26 min
  30. Drug-induced liver injury: risk factors and drug development in DILI

  • Prof. James H. Lewis
• 39 min
  31. Drug-induced liver injury: HDS, diagnosing, treating and preventing DILI

  • Prof. James H. Lewis
• 46 min
  32. An update on the multiple faces of celiac disease

  • Prof. Aaron Lerner
• Immunology
• 51 min
  33. Rac-enhanced CAR immunotherapy: RaceCAR

  • Prof. Denise Montell
• 38 min
  34. Enhancing innate anti-tumour immunity: lessons from virotherapy and STING agonism 1

  • Prof. Kevin Harrington
• 19 min
  35. Enhancing innate anti-tumour immunity: lessons from virotherapy and STING agonism 2

  • Prof. Kevin Harrington
• 56 min
  36. Drug allergy: new knowledge

  • Prof. Mariana C. Castells
• 32 min
  37. Biologics as a treatment strategy in food allergy

  • Prof. Sayantani B. Sindher
• 42 min
  38. B cells at the crossroads of autoimmune diseases

  • Dr. Xiang Lin
• 48 min
  39. Studying immune responses “one cell at a time”

  • Dr. Mir-Farzin Mashreghi
• 43 min
  40. Mathematical modeling in immunology

  • Prof. Ruy M. Ribeiro
• 18 min
  41. Therapeutic antibody development

  • Prof. Dr. Katja Hanack
• 25 min
  42. Understanding treatment coverage in mass drug administrations

  • Dr. Margaret Baker
• 39 min
  43. The thymus and T cell development: a primer

  • Prof. Georg Holländer
• 40 min
  44. The potential of CAR T cells for the treatment of autoimmune diseases

  • Dr. Marko Radic
• Infectious Diseases
• 36 min
  45. The Global Virus Network: collaboration to address pandemic and regional threats

  • Prof. Sten H. Vermund
• 28 min
  46. New concepts in the management of CAP: a focus on severe illness - treatment and therapies

  • Prof. Michael S. Niederman
• 24 min
  47. New concepts in the management of CAP: a focus on severe illness - MRSA and MDR pathogens

  • Prof. Michael S. Niederman
• 46 min
  48. CRISPR-based suppression drives for vector control

  • Prof. Andrea Crisanti
• 39 min
  49. HIV cure: harnessing innate and adaptive strategies

  • Prof. Luis Montaner
• Cardiovascular, Metabolism & Nutrition
• 29 min
  50. Cow’s milk allergy: the future

  • Dr. Carina Venter
• 17 min
  51. Cow's milk allergy: management

  • Dr. Carina Venter
• 50 min
  52. Moving from GWAS hits to functional variants

  • Prof. Steve Humphries
• 44 min
  53. X-linked hypophosphataemia: genetics, diagnosis and management

  • Prof. Thomas O. Carpenter
• 37 min
  54. What is new in type 1 diabetes?

  • Prof. Åke Lernmark
• 35 min
  55. Current concepts for the management of patients with osteoporosis

  • Dr. Michael Lewiecki
• 29 min
  56. Antibodies to control or prevent type 1 diabetes

  • Dr. Robert Hilbrands
• 38 min
  57. Peptide YY (PYY) in obesity and diabetes

  • Dr. Nigel Irwin
• Microbiology
• 39 min
  58. Vaccines and the fight against antimicrobial resistance 1

  • Dr. Annaliesa S. Anderson
• 40 min
  59. Vaccines and the fight against antimicrobial resistance 2

  • Dr. Annaliesa S. Anderson
• 30 min
  60. Vaccines as a weapon against antibiotic resistance

  • Dr. Pumtiwitt McCarthy
• 24 min
  61. PathoLive: pathogen detection while sequencing

  • Dr. Simon Tausch
• 37 min
  62. Translating microbiome research to clinics: trends, directions and challenges

  • Prof. Raj Eri
• 37 min
  63. Successes and failures with vaccines

  • Prof. Stanley Plotkin
• 30 min
  64. Immunology, the microbiome and future perspectives

  • Prof. Sheena Cruickshank
• 22 min
  65. Impact of the HPV vaccine programme – a changing landscape

  • Dr. Kevin Pollock
• Neurology and Neuroscience
• 48 min
  66. Advances in the diagnosis and treatment of tardive dyskinesia

  • Prof. Emeritus Stanley N. Caroff
• 31 min
  67. Cellular therapies for neurological Injuries: bioreactors, potency, and coagulation

  • Prof. Charles S. Cox, Jr.
• 57 min
  68. Cardiovascular involvement in Parkinson’s disease

  • Dr. David S. Goldstein
• 22 min
  69. Molecular brain imaging (PET) in diseases with dementia

  • Prof. Karl Herholz
• 34 min
  70. Current thinking in pain medicine and some thoughts on back pain

  • Dr. Nick Hacking
• 27 min
  71. Bioelectronic medicine: immunomodulation by vagus nerve stimulation

  • Prof. Paul Peter Tak
• 31 min
  72. Developments & future directions in the management of chronic pain

  • Prof. Simon Haroutounian
• 41 min
  73. Deep Brain Stimulation (DBS) neuromodulation for Schizophrenia

  • Prof. Judith Gault
• 39 min
  74. Parkinson’s at 200 years: an update on Parkinson’s research in 2017

  • Prof. Patrick A. Lewis
• 43 min
  75. Alzheimer's disease: where are we up to?

  • Prof. John Hardy
• Pharmaceutical Sciences
• 38 min
  76. Pharmacokinetics, -dynamics and dosing considerations in children

  • Prof. Dr. Karel Allegaert
• 24 min
  77. Why in vitro permeation test – and not in vivo?

  • Prof. Howard Maibach
• 48 min
  78. The future of plasma-derived medicinal products (PDMP)

  • Dr. Daniele Focosi
• 37 min
  79. RNA therapeutics: clinical applications and methods of delivery

  • Prof. John P. Cooke
• 40 min
  80. Recent advances in the development of gene delivery technologies

  • Dr. Takis Athanasopoulos
• 32 min
  81. Preclinical translation of mesenchymal stem cell therapies

  • Dr. Peter Childs
• 20 min
  82. Modulating gene expression to treat diseases

  • Dr. Navneet Matharu
• 38 min
  83. Accelerating drug discovery with machine learning and AI

  • Dr. Olexandr Isayev
• 40 min
  84. AI and big data in drug discovery

  • Mr. Ed Addison
• 44 min
  85. Emerging big data in medicinal chemistry: promiscuity analysis as an example

  • Prof. Dr. Jürgen Bajorath
  • Dr. Ye Hu
• 49 min
  86. Binding kinetics in drug discovery

  • Dr. Rumin Zhang
• 49 min
  87. Modeling of antibody-drug conjugate pharmacokinetics

  • Dr. Dhaval K. Shah
• 35 min
  88. Antibody engineering: beginnings to bispecifics and beyond

  • Dr. Ian Wilkinson
• 51 min
  89. Current challenges in the design of antibody-drug conjugates

  • Prof. L. Nathan Tumey
• 27 min
  90. Inorganic nanostructured interfaces for therapeutic delivery

  • Prof. Tejal Desai
• 32 min
  91. Latest development in therapy-related autophagy research

  • Dr. Vignir Helgason
• Respiratory Diseases
• 29 min
  92. Respiratory syncytial virus vaccination

  • Prof. Peter Openshaw
• 22 min
  93. Advances in gene therapy for respiratory diseases 1

  • Prof. John F. Engelhardt
• 41 min
  94. Advances in gene therapy for respiratory diseases 2

  • Prof. John F. Engelhardt
• 37 min
  95. Asthma

  • Prof. William Busse
  • Dr. Amanda McIntyre
• 45 min
  96. New drugs for asthma

  • Prof. Peter Barnes
• 29 min
  97. CompEx asthma: a novel composite exacerbation endpoint

  • Dr. Carla A. Da Silva
• 42 min
  98. Updates in chronic obstructive pulmonary disease (COPD)

  • Dr. Omar S. Usmani

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Cancer-centric view
3. Issues with the cancer-centric view
4. THE CANCER IS SURROUNDED BY THE PATIENT
5. The cancer patient
6. Tumor Organismal Environment (TOE)
7. Overview of the Tumor Microenvironment (TME)
8. Plants and their immediate environment
9. Differential effects of ECM proteins on actin and focal adhesions
10. ECM proteins impact lung metastasis formation
11. The in vivo environment accelerates tumorigenesis
12. The Tumor Microenvironment (TME)
13. Principles of intra-TME interactions
14. Heraclitus
15. Bidirectional crosstalk
16. Principles of intra-TME interactions: Tumor progression
17. Tumor progression and regression
18. Tumor dormancy
19. Principles of intra-TME interactions: Pro- or anti-malignancy functions
20. Principles of intra-TME interactions: Hijacking physiological elements
21. Tumor cells hijack physiological elements
22. Principles of intra-TME interactions: Different tumor microenvironments
23. Metastasis kills
24. Site-specific metastasis
25. Early observations on site-specific metastasis
26. Stephen Paget
27. The TME shapes the phenotype of the tumor
28. The pre-metastatic niche
29. Formation of the pre-metastatic niche
30. Tumor-derived extracellular vesicles (EVs) and the pre-metastatic organ
31. The metastatic cascade (1)
32. Regulation of the metastatic cascade
33. Epithelial to Mesenchymal Transition (EMT)
34. The TME regulates the EMT
35. The metastatic cascade (2)
36. Intravasation
37. Circulating cancer cells interact with platelets
38. The role of platelets
39. Extravasation
40. Extravasation steps of cancer cells
41. Selectins and tumor cell rolling
42. The functional role of integrins in extravasation
43. Integrins involved in the firm adhesion of tumor cells to the endothelium
44. Chemokine receptor-mediated migration
45. Targeted migration of chemokine receptor-expressing cancer cells
46. The fate of tumor cells at metastatic organ sites
47. Metastatic-promoting and metastatic-restraining factors
48. Metastasis-restraining signals
49. The short peptide of human HBB (Metox) inhibits tumor growth
50. Metox inhibits neuroblastoma metastasis
51. Interactions between tumors and their microenvironment
52. Targeting tumor-TME interactions
53. 2018 Nobel Prize laureates James Allison & Tasuku Honjo
54. Immune checkpoint blocking enables TME-infiltrating T cells to kill tumor cells
55. A history of exploring cancer in context
56. A rephrased statement of Stephen Paget (IPW)
57. Witz Team 2020-2021
58. My sincere thanks

Topics Covered

• Tumor Organismal Environment (TOE) and Tumor Microenvironment (TME)
• Principles of intra-TME interactions
• Tumor progression and regression
• Site-specific metastasis
• The pre-metastatic niche
• The metastatic cascade
• Epithelial to Mesenchymal Transition (EMT)
• Targeting tumor-TME interactions
• Immune checkpoint blocking enables TME-infiltrating T cells to kill tumor cells

Links

Series:

• Periodic Reports: Advances in Clinical Interventions and Research Platforms

Categories:

• Cancer
• Clinical Practice

Therapeutic Areas:

• Oncology

Talk Citation

Publication History

• Published on March 31, 2021

Financial Disclosures

• Prof. Isaac P. Witz has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.