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1. Introduction
2. Invasive growth is triggered by specific signals
3. Invasive growth is a response to scatter factors
4. Invasive growth is a response to semaphorins
5. Invasive growth receptors
6. The "receptosome"
7. Invasive growth signaling
8. Specificity of signal transduction for invasive growth
9. The Met "transcriptome"
10. Gene expression profiling with microarrays
11. HGF regulated genes
12. Invasion and metastasis
13. Inappropriate activation of MET oncogene
14. Hypoxia regulates MET transcription
15. HRE and AP-1 site in MET transcription
16. Hypoxia controls MET expression at transcription
17. MET is overexpressed in hypoxic areas of tumors
18. Invasive growth as an escape mechanism
19. Invasive growth is driven by hemostatic genes
20. Somatic vs. germline oncogene delivery
21. MET induces liver pre-neoplastic nodules
22. MET transduction causes thrombohemorrhage
23. MET causes liver cancer and DIC syndrome
24. Thrombohemorrhage precedes cancer onset
25. Trousseau's syndrome
26. Expression profiling of transduced MLP-30
27. Expression profiling of transduced hepatocytes
28. MET affects PAI-1 expression
29. MET affects Cox-2 expression
30. The hypothesis
31. Preventing invasive growth
32. Decoy Met
33. Decoy inactivates HGF receptors
34. Delivering HGF-antagonists to tumors
35. Systemic delivery of HA
36. Parameters of mice transduced with decoy MET
37. Decoy MET inhibits tumor growth and metastasis
38. Anti-MET Mab inhibits tumor growth and metastasis
39. Summary
40. Credits
41. Thanks

Topics Covered

• Trigger of invasive growth by specific signals
• Invasive growth receptors
• The "receptosome"
• Dynamics of invasive growth signalling
• The MET transcriptome
• HGF regulated genes
• Hypoxia regulates MET transcription
• The effector machinery of invasive growth: the coagulation cascade
• HGF antagonists impair tumor growth and metastasis: a gene therapy strategy

Links

Series:

• Signal Transduction via Protein Tyrosine Kinase Receptors

Categories:

• Cancer
• Cell Biology
• Reproduction & Development

Therapeutic Areas:

• Oncology

Talk Citation

Comoglio, P. (2007, October 1). The HGF receptor, a targettable regulator of invasive growth [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 23, 2024, from https://doi.org/10.69645/EUWX3306.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on October 28, 2018

Financial Disclosures

• Prof. Paolo Comoglio has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.