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Navigable Slide Index

1. Introduction
2. Potential metabolic fates of pyruvate
3. Lactate transport
4. Pyruvate dehydrogenase complex
5. Importance of maintaining flux via PDC
6. Impact of excessive flux via PDC
7. Allosteric regulation of PDC
8. Covalent regulation of PDC
9. Mechanisms of activation of PDC
10. Regulation of PDP isoforms
11. Mechanisms of suppression of PDC
12. PDK expression
13. Site specificity of PDC phosphorylation
14. Impairing PDC reactivation by PDK4
15. PPAR-alpha
16. PDK expression in Morris hepatoma 7800 C1 cells
17. Regulation of PDK4 expression
18. Consequence of a low PDC activity (liver)
19. Anaplerosis and cataplerosis
20. Pyruvate carboxylase
21. Physiological roles of cataplerosis in liver
22. Insulin secretion in relation to pyruvate handling
23. Glucose/fatty-acid cycle - high lipid utilisation
24. Upregulation of PDK expression
25. Acute regulation of PDK by metabolites
26. PDK isoforms change PDC activation sensitivity
27. PGC-1alpha
28. Regulation of skeletal muscle pyruvate disposition
29. Skeletal muscle fuel handling
30. Insulin resistance and metabolic inflexibility
31. Insulin resistance modifies muscle PDK and PDC
32. Consequences of PDK4 upregulation
33. Disorders of pyruvate handling: PDC deficiencies
34. Disorders of pyruvate handling: PC deficiencies

Topics Covered

• Potential metabolic fates of pyruvate
• Lactate transport
• Role of pyruvate dehydrogenase complex (PDC)
• Regulation of PDC
• Mechanisms of activation of PDC by pyruvate dehydrogenase phosphatases
• Pyruvate dehydrogenase kinase (PDK) expression and regulation
• Multi-site phosphorylation
• Transcription factors regulating PDK4 expression
• Anaplerosis and cataplerosis
• Pyruvate carboxylase
• Insulin secretion and action
• Glucose/fatty-acid cycle
• Consequences of PDK4 upregulation
• Disorders of pyruvate handling

Links

Series:

• Protein Epidemiology

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Sugden, M. (2007, October 1). Modifications of pyruvate handling in health and disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/UTDT5839.
Export Citation (RIS)

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Mary Sugden has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.