• Structure of PTK receptors and regulation of their kinases
• 45 min
  1. EGF receptor family: targets for improving cancer therapy

  • Prof. Tony Burgess
• Intracellular signal transduction by PTK receptors
• 45 min
  2. PI 3-kinases and lipid messengers

  • Prof. Bart Vanhaesebroeck
• 29 min
  3. The ERK1/2 MAPK cascade

  • Prof. Melanie H. Cobb
• Archived Lectures *These may not cover the latest advances in the field
• 41 min
  4. Structural biology of FGF signaling in human development and disease

  • Dr. Moosa Mohammadi
• 49 min
  5. RTKs activate the ERK 1/2 MAPK cascade

  • Prof. Melanie H. Cobb
• 36 min
  6. The Eph receptor family

  • Prof. Elena Pasquale
• 31 min
  7. The molecular basis of insulin action

  • Prof. Morris White
• 46 min
  8. EGF receptor family: targets for cancer therapeutics

  • Prof. Tony Burgess
• 53 min
  9. Receptor tyrosine kinases - function, families and evolution

  • Prof. Tony Hunter
• 35 min
  10. The epidermal growth factor receptor family: roles in development and cancer

  • Prof. Nancy Hynes
• 18 min
  11. How the PDGF receptor induces cell proliferation

  • Dr. Andrius Kazlauskas
• 31 min
  12. VEGF inhibitors for anti-angiogenic therapy

  • Prof. Kari Alitalo
• 30 min
  13. Structure and mechanism of the tyrosine kinase domain of the insulin receptor

  • Dr. Stevan Hubbard
• 50 min
  14. Activation of PTK receptors in solid human tumors

  • Dr. Marco Pierotti
• 40 min
  15. Negative regulation of RTKs: receptor ubiquitylation, endocytosis and feedback loops

  • Prof. Yosef Yarden
• 61 min
  16. SH2-containing PTPs (Shps) in RTK signaling and disease

  • Prof. Benjamin G. Neel
• 51 min
  17. Modular protein-protein interactions provide a general mechanism to organize dynamic cellular systems

  • Prof. Tony Pawson
• 43 min
  18. Phospholipase C gamma

  • Prof. Graham Carpenter
  • Ms. Cornelia Crooke
• 38 min
  19. Imatinib as a paradigm of targeted cancer therapies

  • Prof. Brian Druker
• 42 min
  20. EGFR targeted therapies in lung cancer

  • Dr. Pasi Janne
• 36 min
  21. The VEGF family

  • Prof. Kari Alitalo
• 33 min
  22. The HGF receptor, a targettable regulator of invasive growth

  • Prof. Paolo Comoglio

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Mechanisms to diabetes
3. The insulin response
4. Growth factor receptor tyrosine kinases
5. Insulin and its receptor
6. Insulin receptor
7. Insulin receptor transmembrane signaling
8. Insulin and IGF1 receptors exist as hybrids
9. Growth factor receptor tyrosine kinases
10. The substrate hypothesis of insulin action
11. The family of Irs-proteins
12. Insulin signaling cascade
13. Insulin stimulates GLU4 translocation
14. The insulin signaling cascade
15. The insulin signaling cascade inhibition
16. IRS-proteins mediated insulin action
17. IRS2 integrates central & peripheral homeostasis
18. IRS2 regulates hepatic glucose homeostasis
19. IRS2 signaling promotes glucose homeostasis
20. IRS signaling regulates the expression of Pdx-1
21. Integrated view of IRS signaling system

Topics Covered

• Mechanisms to diabetes
• The insulin response
• Growth factor receptor tyrosine kinases
• The insulin receptor
• The substrate hypothesis of insulin action
• The family of Irs-proteins
• The insulin signaling cascade
• Role of the Irs2 signaling system

Links

Series:

• Signal Transduction via Protein Tyrosine Kinase Receptors

Categories:

• Biochemistry
• Cell Biology
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 28, 2025

Financial Disclosures

• Prof. Morris White has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.