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1. Introduction
2. The history of protein phosphorylation (1)
3. The history of protein phosphorylation (2)
4. The history of protein phosphorylation (3)
5. The history of protein phosphorylation (4)
6. The history of protein phosphorylation (5)
7. The history of protein phosphorylation (6)
8. The history of protein phosphorylation (7)
9. The history of protein phosphorylation (8)
10. The history of protein phosphorylation (9)
11. Stone age bioinformatics!
12. Eukaryotic kinases have related catalytic domains
13. PKA catalytic subunit bound to PKI and ATP
14. A thousand and one protein kinases
15. How many tyrosine kinases are there? (1)
16. How many tyrosine kinases are there? (2)
17. The history of tyrosine phosphorylation
18. Reactions by kinases and phosphatases
19. Unactivated insulin receptor TK catalytic domain
20. Tyrosine phosphorylation and human disease (1)
21. Tyrosine phosphorylation and human disease (2)
22. How many protein kinases are there?
23. Evolutionary kinomics: protein kinase families
24. How many human PK and phosphatases? (1)
25. How many human PK and phosphatases? (2)
26. The human kinome (1)
27. The human kinome (2)
28. Human tyrosine kinases
29. What is tyrosine phosphorylation used for?
30. Nonreceptor tyrosine kinases
31. Receptor tyrosine kinases (1)
32. TM signaling by tyrosine phosphorylation
33. RTK dimerization and catalytic activation
34. FGF receptor dimer with bound FGF and heparin
35. Mechanisms of RTK dimerization and activation
36. Structural transition from IRK-0P to IRK-3P
37. Receptor tyrosine kinase classes
38. PDGF RTK activation and signaling
39. Modular interac. domains in signal transduction
40. RTK signaling through SH2 and PTB domains
41. RTK signaling via the Grb2 SH2/SH3 adaptor
42. Paradigms for signal pathway activation by RTK (1)
43. Paradigms for signal pathway activation by RTK (2)
44. Paradigms for signal pathway activation by RTK (3)
45. Targets for receptor tyrosine kinases
46. PDGF RTK activation and signaling
47. PDGF receptor tyrosine kinase signaling
48. Receptor Tyrosine Kinases (2)
49. Insulin receptor tyrosine kinase signaling (1)
50. Insulin receptor tyrosine kinase signaling (2)
51. Insulin RTK signaling pathways
52. Insulin/IGF1-IRS-PI3 kinase-mTOR signaling
53. Tumor suppressors in PI3K/Akt/mTOR pathway
54. TSC1 or TSC2-null MEFs show reduced IRS1
55. mTOR dependent negative feedback loop
56. Expression of Rheb decreases IRS levels
57. Inhibitory effects of Rheb reversed by mTOR
58. Inhibitory effects of Rheb reversed by S6K1
59. Negative feedback loop reduces insulin signaling
60. Multiple serine kinases act on IRS1 (1)
61. Multiple serine kinases act on IRS1 (2)
62. Model for Rheb/mTOR/S6K negative feedback
63. Receptor Tyrosine Kinases (3)
64. Eph family receptor tyrosine kinases (1)
65. Eph family receptor tyrosine kinases (2)
66. Ephs and ephrins mediate bidirectional signaling
67. Repellant and attractant guidance cues
68. coexpression of EphA and ephrin-A proteins
69. Exogenous proteins trigger opposing responses
70. Ephrin-A does not reduce EphA receptor activation
71. Discrete EphA and ephrin-A localiza. in motor axon
72. Differential membrane localization of EphA, ephrinA
73. Domain-swapping chimeras
74. Targeting ephrin-A to EphA membrane domains (1)
75. Targeting ephrin-A to EphA membrane domains (2)
76. Targeting EphA to ephrin-A membrane domains
77. Compartmentalization insulates receptor diversity
78. Protein kinases are implicated in diverse diseases
79. Human cancer genes
80. Cancer and the kinome
81. Protein kinases/phosphatases and cancer (1)
82. Protein kinases/phosphatases and cancer (2)
83. The long road to the GLEEVEC cancer drug
84. Acknowledgments

Topics Covered

• History of protein phosphorylation
• Protein kinase bioinformatics
• History of tyrosine phosphorylation and functions of tyrosine kinases
• Genomic catalogues of protein kinases (kinomes)
• The human kinome
• The evolution of kinomes
• The human tyrosine kinase subfamily
• Receptor and nonreceptor tyrosine kinases
• Activation of receptor tyrosine kinases by ligand-induced dimerization
• Signal transduction pathways downstream of receptor tyrosine kinases
• Insulin and IOGF-1 receptor signaling via the mTOR pathway
• mTOR-S6 kinase feedback loop leading to downregulation of the IRS1 docking protein and insulin resistance
• History of Eph receptor tyrosine kinases and their ephrin ligands
• Bidirectional signaling via Eph-ephrin interactions on neighboring cells
• Simultaneous signaling by EphAs and ephrin As in motor neurons
• Compartmentalized signaling by receptor tyrosine kinases and their ligands through localization to discrete membrane domains
• Protein kinases and human disease
• Human cancer genes and protein kinases
• Protein kinases and phosphatases and cancer
• The long road to Gleevec

Links

Series:

• Signal Transduction via Protein Tyrosine Kinase Receptors
• The World of Hormones

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Hunter, T. (2007, October 1). Receptor tyrosine kinases - function, families and evolution [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 23, 2024, from https://hstalks.com/bs/447/.
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Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Tony Hunter has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.