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Printable Handouts
Navigable Slide Index
- Introduction
- The adaptive immune system
- Adaptive immunity
- Antibody-mediated immunity
- Basic mechanisms of adaptive immunity
- Lymphocytes mediate adaptive immunity
- The time course of an antibody response
- B cell-mediated antibody response
- Antibodies
- Immune response is improved in adaptive immunity
- IgG
- IgM
- IgA
- IgE
- Immunologic memory
- Structure of a plasma cell
- Picture of plasma cells
- Cell-mediated immunity
- Adaptive immunity: a reminder
- Basic mechanisms of adaptive immunity
- Organ graft rejection
- Time course of graft rejection
- Poison ivy: a cell-mediated response
- Cell-mediated immunity: a summary
- B cells and T cells
- Cellular cytotoxicity
- The process of apoptosis
- The process of cell-mediated immunity (1)
- The process of cell-mediated immunity (2)
- Macrophage activation
- Example of tuberculosis infection
- Time course of a tuberculosis infection in cattle
- “Alternative activation”
- Cytokines of the immune system
- What happens if an animal mounts the “wrong” response?
- Veterinary vaccines
- Maternal immunity
- Animal allergies
- Autoimmune diseases
- Key points
- Thank you!
Topics Covered
- Characteristics of adaptive immunity
- The involvement of B and T cells in adaptive immunity
- Diverse types of antibodies
- Immunological memory
- Control of adaptive immunity
- Autoimmunity and allergies in animals
- Vaccines in domestic animals
Talk Citation
Tizard, I. (2020, November 30). An introduction to veterinary immunology: adaptive immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 5, 2024, from https://doi.org/10.69645/LHWL8043.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
An introduction to veterinary immunology: adaptive immunity
Published on November 30, 2020
34 min
A selection of talks on Immunology
Transcript
Please wait while the transcript is being prepared...
0:02
Let's now move to the adaptive immune system.
This is a much more sophisticated, much more complex,
and much more important immune system for the defense of the animal body.
Every animal has it.
If you don't have it, you die.
0:21
Now, in looking at adaptive immunity,
the key thing to remember is that there are two major groups of microbial invaders.
We have the bacteria plus some protozoan,
a few worms that live outside cells.
They grow in tissue spaces.
Then you also have intracellular invaders such as the viruses,
some bacteria, and few protozoa that get inside cells.
The body needs two different mechanisms to
fight the extracellular invaders and the intracellular invaders.
It uses proteins called antibodies to fight extracellular invaders,
and it uses a cell-mediated immune response to fight viruses;
the invaders inside cells.
This is a key division in adaptive immunity and are quite important,
for example in using vaccines and developing vaccines.
We need two different sorts of adaptive immune response.
1:22
Let's talk first of all about antibody-mediated immunity.
Antibodies are proteins that are produced by
the body and released either into the bloodstream or onto body surfaces.
Now, as we pointed out before,
there's a diverse array of different microbes that are attacking
the body and we therefore need different antibodies for different purposes.
Some antibodies protect the inside of the body,
some antibodies protect the surface of the body.
What they do, is they mark invaders for destruction.
They bind invading organisms,
mark them for destruction.
They only work outside cells,
so only if the organism is outside a cell will antibodies work.
The term we use to describe this sort of immunity is also called humoral immunity,
because antibodies are found in body fluids.