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1. Introduction
2. Some basic time scales in folding (1)
3. Loop formation times
4. Chain relaxation times
5. Some basic time scales in folding (2)
6. Folding as a unimolecular reaction
7. Classical transition state theory (TST)
8. Folding is diffusion-controlled
9. Diffusion driven barrier-crossing
10. Kramers behavior in folding simulations
11. Viscosity dependence of DNA hairpin closure
12. Folding: is friction due to solvent alone?
13. Solvent viscosity and peptide loop formation
14. Internal friction and polymer dynamics
15. Internal friction due to backbone rotations
16. Internal friction in conformational dynamics
17. Viscosity effects in protein folding
18. Other complications in viscosity studies
19. Internal friction in folding? (I)
20. Internal friction in folding? (2)
21. Internal friction in folding? (3)
22. Preparing a "friction-limited" system
23. Laser-triggered folding kinetics
24. Folding time vs. solvent viscosity
25. Comparing two IF experiments
26. Reaction-coordinate dependent diffusion constant
27. Large activation energy for t-0
28. Tryptophan Cage (Tc5b)
29. Viscosity dependence at constant delta G
30. TrpCage k-f and k-u
31. Compare to k-f simulations
32. Limiting folding/unfolding times
33. Conclusions
34. Acknowledgments

Topics Covered

• Basic time scales and diffusional limits in protein folding
• Applying reaction rate theories to folding
• Kramers behavior and friction
• Internal friction of polymer chains
• Evidence for (or against) internal friction in protein folding
• Fast folding experiments and methodology
• Interpretations: internal time scales versus internal viscosity
• Limitations of the "diffusional limits" picture

Links

Series:

• Protein Folding, Aggregation and Design

Categories:

• Biochemistry

Talk Citation

Hagen, S. (2007, October 1). Fast folding dynamics of small proteins: placing limits on diffusional limits [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/MSOP5589.
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Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Dr. Stephen Hagen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.