Evolution of the protein to withstand stress from mutation, the environment and to withstand mechanical force in the muscle
Use of a combination of protein engineering, kinetic and thermodynamic measurements, computer simulations and single molecule atomic force microscopy to understand how evolution acts on protein sequences to allow them to adapt to stressful conditions, probably explaining why immunoglobulin-like proteins are used so successfully in evolution to perform a number of functions
Clarke, J. (2007, October 1). Titin I27: a protein with a complex folding landscape [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 20, 2021, from https://hstalks.com/bs/432/.
Published on October 1, 2007
Archived on April 17, 2016
Dr. Jane Clarke has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.