My name is Naoto Ueno.
I am the Executive Director of Morgan
Welch Inflammatory Breast Cancer Research
Clinic at MD Anderson Cancer Center.
Today I am going to be talking about
"Targeting Cancer Microenvironment",
inflammatory breast cancer management.
This picture depicts typical appearance
of inflammatory breast cancer.
You can see that right breast is engorged
and there is some slight redness.
And you can see the edema.
A 'peau d'orange' changes are also
another typical change that we see.
The question remains,
what are the mechanistic underlying things
contributing to the cause
of this erythema?
One of the mechanism that people
have been speculating is that,
from the pathology perspective,
there is a tumor emboli in the dermal
lymphatic channel that causes
skin inflammatory changes.
The question remains that whether
these inflammatory changes are simply
immunological or true inflammation,
and that remains unknown.
This review paper actually talks
about different aspects of potential
causes of inflammatory breast cancer.
So inflammatory breast cancer is one
of the most aggressive breast cancer.
It represents about 2 to 4% of
breast cancer in the United States.
When you look from the perspective of the
breast cancer deaths in the United States,
it represents about 10%.
Now in North and Western Africa,
such as Egypt, Tunisia,
Senegal, it is a major health issue,
because inflammatory breast
cancer represents about 15%.
Also, the limited healthcare access
results in a higher rate of breast
The appearance I have shown you before,
commonly is misdiagnosed as mastitis,
because it looks inflamed and
it is probably appropriate to say
that this appears like mastitis.
So therefore treating with antibiotics
is a first round of clinical practice.
But once the antibiotic is not working,
we need to consider that there is a
possibility of inflammatory breast cancer.
The other thing that we have to remember
is that this type of breast cancer does
not always have a mass.
If you do a mammogram, roughly 30 to
40% of women will not have any mass,
and that's where the confusion starts,
because our general
expectation about breast cancer is
that you're supposed to see a mass.