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- 2023
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1. Planning and response to COVID-19: lessons from China and South-East Asia
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2. The emergence of the SARS-CoV-2 Omicron variant
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3. How is Omicron different?
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5. Potential of ‘long-COVID’ in triggering chronic co-pathologies
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6. SARS-CoV-2 monoclonal antibody testing in vivo
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7. mRNA COVID-19 vaccine efficacy in recovered vs COVID-naive individuals
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8. SARS-CoV-2 variants: implications for immunity and vaccine development
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10. SARS-COV-2 human monoclonal antibody therapy update
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11. Emergence of blood clotting disorders resulting from COVID vaccines inoculations
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12. SARS-CoV-2 evolution within and between individuals
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13. Identifying SARS-CoV-2 proteases
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14. Genetic surveillance and the emergence of SARS-CoV-2 variants
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15. The COVID-19 outbreak: April 2021 update
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16. ABO blood groups and SARS-CoV-2 susceptibility
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17. Impact of COVID-19 on neuropsychiatric disorders and mental health
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18. The immune system response to the SARS-CoV-2 virus: March 2021 update
- Prof. Paul Klenerman
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23. SARS-CoV-2 vaccine rollout campaigns
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25. Interspecies transmission of SARS-CoV-2
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26. Complement activation in COVID-19
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27. Human movement patterns and local spread of COVID-19
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28. SARS-CoV-2 mutations: phenotypes and implications for vaccine development
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29. The immune system response to the SARS-CoV-2 virus: December 2020 update
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30. Triage and end of life care planning in COVID-19
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31. Natural killer cells as COVID-19 therapy
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32. Update on the SNG001 drug, an INFβ therapy for COVID-19
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34. Identification of a new coronavirus-specific RNA export protein complex
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35. The neurological symptoms of COVID-19
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36. Imperial College London’s saRNA Vaccine - COVAC1
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37. Interferon-α2b as a therapy for COVID-19
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38. Potential long-term health effects of a SARS-CoV-2 infection
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39. The COVID-19 coronavirus outbreak: October 2020 update
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41. Rheumatic diseases and COVID-19
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42. The cardiovascular complications of SARS-CoV-2 infection
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43. Medical wearable devices for tracking symptoms of COVID-19
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44. Risk of re-emergence of COVID-19 after exit from lockdown
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45. The evolutionary origin of SARS-CoV-2
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46. Predicting COVID-19 outbreaks by measuring SARS-CoV-2 RNA in sewage sludge
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47. Approaches for elucidating genetic susceptibility to SARS-CoV-2
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48. The immune system response to the SARS-CoV-2 virus: July 2020 update
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49. The impact of COVID-19 in the elderly and in care homes
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50. Human challenge trials for vaccines against COVID-19
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51. The development of SARS-CoV-2 vaccines
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52. Convalescent plasma therapy as a treatment for COVID-19
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53. Remdesivir COVID-19 clinical trial
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54. Nanotechnologies in the fight against coronaviruses
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55. The COVID-19 coronavirus outbreak: May 2020 update
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56. INFβ therapy for COVID-19: the new SNG001 drug
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57. Strategies for exiting the lockdown
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58. SARS-CoV-2 human monoclonal antibody therapy
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59. An FDA approved salivary test for SARS-CoV-2 infection
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60. Development of an intranasal vaccine for SARS-CoV-2
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61. The immune system response to the SARS-CoV-2 virus: an update
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62. A novel AIOD-CRISPR system for diagnosis of SARS-CoV-2
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63. Development of PRO-140 (Leronlimab) as a treatment for COVID-19
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64. COVID-19 epidemiology and potential treatments: follow up interview
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65. SARS-CoV-2 vaccine development: where are we now?
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66. SARS-CoV-2: What we need to know and possible future therapies
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67. SARS-CoV-2 vaccine: current biological targets and considerations
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68. The current understanding of the biology of the SARS-CoV-2 virus
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70. The immune system response to the SARS-CoV-2 virus
- Prof. Paul Klenerman
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71. SARS-CoV-2 vaccine development
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72. The COVID-19 outbreak: an update on the SARS-CoV-2 virus
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73. The COVID-19 coronavirus outbreak: a current view
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74. The COVID-19 coronavirus outbreak: March 2020 update
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Topics Covered
- Updated knowledge on the immune response to SARS-COV-2
- Antibody tests and their future role
- Current knowledge on how the lungs are being affected during infection
- A hypothesis on why age ranges respond differently to infection
- Animal models to study SARS-COV-2 infection
Biography
Paul Klenerman trained in medicine at Cambridge and Oxford and specialised in infectious diseases. He did his PhD in viral immunology at Oxford University and a postdoc in Zurich before returning to Oxford to establish a lab looking at immune responses to infection. The work includes studies of hepatitis C and a range of viruses affecting the lungs and liver - looking at how these evade the immune response, and the development of vaccines. He is focused especially on novel T cell responses in the mucosal surfaces which are critical for early host defence. He is an NIHR senior fellow and a Wellcome Trust investigator and holds a chair in the Nuffield Department of Medicine in Oxford.
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Talk Citation
Klenerman, P. (2020, April 27). The immune system response to the SARS-CoV-2 virus: an update [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 27, 2024, from https://hstalks.com/bs/4269/.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Respiratory Diseases
Transcript
Please wait while the transcript is being prepared...
0:00
Interviewer: Hello Professor Klenerman,
thank you for taking the time to do this
update interview after your last
interview recorded with us last month.
What are some of the key
points of knowledge that
we now know about how the immune system
responds to the SARS-CoV-2 virus?
Prof. Klenerman: Lots of
work has been done, and
things are emerging in the literature
often in pre-print format (so they haven't
been formally peer-reviewed), but you get
a glimpse of what people are thinking.
I think the biggest change since we first
spoke has been the development of antibody
tests, I know these have been in the news
a lot with some doom and gloom about them,
but underneath all that there's
been a massive amount of progress.
The development of an antibody
test tells you a couple of things.
One is: what is the quality of the
antibody response against this virus and
how does that relate to disease and
protection?
The other is more general: who has been
exposed to this virus, how far it has
spread through the community and
if you've set up the right sort of study.
The first thing that happened, and it all
happened very fast, was the development of
these lateral-flow assays, or
stick tests, that have been tested.
The problem with those is that although
they are reasonably specific for
whether you have or haven't had COVID-19,
they're not very sensitive,
and not really good enough generally
to be used for diagnostic purposes.
If you are positive on one of those, it's
pretty likely you have been exposed to
the virus, but if you're negative,
you could well have been exposed and
it just misses that, so
the sensitivity is not fantastically high.
The only reason we know that is because
there are much better tests that work in