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Navigable Slide Index

1. Introduction
2. Alzheimer's disease (AD)
3. Neuropathological lesions associated with AD
4. Neurofibrillary tangles
5. Beta-amyloid plaques
6. Alzheimer amyloid precursor protein (APP)
7. APP is cleaved by alpha-secretase
8. APP is cleaved by beta-secretase
9. Cleavage by gamma-secretase
10. Generation of A-beta-42
11. Genetic studies
12. Genetics of Alzheimer's disease
13. APP mutations cluster around secretase sites
14. Presenilin and its interactions
15. Presenilin (PS1 and PS2)
16. Presenilin functions
17. FAD-associated presenilins mutations
18. Calcium homeostasis
19. PS and Ca2+ homeostasis
20. FAD-PS1 potentiates calcium release
21. Calcium signaling studies
22. Ca2+ dyshomeostasis and Alzheimer's disease
23. Presenilins have a physiological modulatory role
24. A new PS function
25. Two new FAD-linked PS2 mutations
26. PS2 mutations: M239I and T122R
27. FAD-linked PS2 mutations reduce Ca2+ release
28. Other FAD linked mutations
29. A genetically encoded luminescent Ca2+ sensor
30. Effects of PS mutants on cytosolic Ca2+
31. Cytosolic Ca2+ changes
32. Effects on ER calcium content
33. Effects on Golgi calcium content
34. Mechanism(s)?
35. PS2 mutants increase Ca2+ leak
36. PS2 mutants inhibit SERCA pump
37. PSs might be multi-functional proteins
38. Discordance with the literature?
39. An exaggerated Ca2+ response
40. Exaggerated Ca2+ release hypothesis for AD
41. Does PS affect mitochondria Ca2+ handling
42. PS2 expression favors Ca2+ uptake
43. PS2 increases ER-mitochondria interaction
44. PS2 modulates ER-mitochondria tethering
45. A reformulation of the Ca2+ hypothesis for FAD
46. References

Topics Covered

• Introduction to Alzheimer's disease
• Morphological and functional features
• Genetic studies
• Presenilin functions and calcium homeostasis
• Calcium dyshomeostasis and FAD
• Modulatory role of presenilin on IP3-evoked Calcium release
• Different effects of PS mutants on intracellular Calcium stores
• A reformulation of the 'Calcium hypothesis' for FAD

Links

Series:

• Calcium Signaling I
• Calcium Signaling II

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Pizzo, P. (2011, July 27). Ca2+ alterations in familial Alzheimer's disease (FAD) [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/MWJJ2931.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Updated on July 27, 2011

Financial Disclosures

• Dr. Paola Pizzo has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.