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Navigable Slide Index

1. Introduction
2. Outline
3. The polycystic kidney disease (PKD)
4. Clinical aspects of ADPKD
5. Genetic aspects of ADPKD
6. PKD mutations are somatically recessive
7. The products of PKD1 and PKD2 : polycystins
8. Polycystin (1)
9. Polycystin (2)
10. Properties of the PC2 channel
11. PC1 and PC2: a receptor channel complex
12. Subcellular localization of PC1 and PC2
13. The PC1 and PC2 complex is conserved
14. Primary cilium and cystic kidney disease
15. Mechanosensory function of PC1/PC2 complex
16. PC1 and PC2 signaling
17. PC1, PC2 and calcium homeostasis
18. PC1, PC2 and calcium levels in kidney cells
19. PC1 and endoplasmic reticulum calcium uptake
20. PC1 tail expression and NFAT activation
21. PC1, cytoplasmic Ca levels and cell proliferation
22. PC1 expression and cell proliferation
23. Cross-talk between calcium and cAMP signaling
24. Polycystin calcium signaling

Topics Covered

• Clinical and genetic aspects of polycystic kidney disease
• The polycystins (PC1, PC2)
• The PC2 channel
• PC1 and PC2 subcellular location and interaction
• Mechanosensory function of the ciliary PC1/PC2 complex
• PC signaling and calcium homeostasis
• PC1, calcium levels and cell proliferation
• PC1, cAMP signaling and cell proliferation
• PCs and physiopathologic calcium signaling

Links

Series:

• Calcium Signaling I
• Calcium Signaling II

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Gastroenterology & Nephrology

Talk Citation

del Senno, L. (2007, October 1). Polycystins, calcium signaling and pathogenesis of polycystic kidney disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/ZQAE6412.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Laura del Senno has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.