• Introduction to Calcium Signaling
• 72 min
  1. Introduction to cellular calcium signaling

  • Dr. Martin Bootman
• 20 min
  2. Monitoring Ca2+ concentration in living cells

  • Dr. Marisa Brini
• 30 min
  3. Cell boundary theorem

  • Prof. Eduardo Ríos
• Calcium Influx
• 19 min
  4. Arachidonic acid and store-independent Ca2+ entry

  • Dr. Luca Munaron
• 34 min
  5. Voltage-dependent calcium channels

  • Prof. Annette Dolphin
• 34 min
  6. Protein networks of voltage-gated Ca2+ channels – proteomic & functional analysis of local Ca2+ signalling

  • Prof. Bernd Fakler
• 37 min
  7. Intracellular Ca2+ signaling: calcium influx

  • Prof. Anant Parekh
• 60 min
  8. Molecular identification of the CRAC channel

  • Prof. Michael Cahalan
• 35 min
  9. TRP channels with diverse permeability profiles: regulation of blood pressure and fertility

  • Prof. Marc Freichel
• Calcium Release
• 47 min
  10. The molecular biology of the inositol trisphosphate receptor

  • Dr. Randen Patterson
• 53 min
  11. The InsP3 receptor calcium release channel

  • Prof. J. Kevin Foskett
• 31 min
  12. Molecular biology of ryanodine receptors

  • Dr. Christopher George
  • Prof. F. Anthony Lai
• 57 min
  13. cADPR and NAADP: messengers for calcium signalling

  • Prof. Antony Galione
• 50 min
  14. Coordinated Ca2+ release from intracellular Ca2+ stores

  • Prof. Ole Petersen
• 43 min
  15. Ryanodine receptors and cardiac function

  • Prof. David Eisner
• Calcium Efflux and Sequestration
• 45 min
  16. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology

  • Prof. Ernesto Carafoli
• 60 min
  17. The calcium saga: a matter of life and death

  • Prof. Pierluigi Nicotera
• 45 min
  18. Sodium-calcium exchange

  • Prof. John Reeves
• 22 min
  19. Ca2+ efflux and Ca2+ signals

  • Dr. Anne Green
• Organelle Calcium
• 42 min
  20. Regulation and role of mitochondrial Ca2+ homeostasis

  • Prof. Rosario Rizzuto
• 54 min
  21. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis

  • Dr. Paola Pizzo
  • Dr. Alex Costa
• 31 min
  22. Organellar calcium pumps of the golgi and ER: from yeast to human

  • Prof. Rajini Rao
• 34 min
  23. Ca2+ dynamics between mitochondria and the endoplasmic reticulum

  • Dr. Wolfgang Graier
• 26 min
  24. Nuclear calcium signaling

  • Dr. Oleg Gerasimenko
  • Dr. Julia Gerasimenko
• Spatiotemporal Calcium Signals
• 58 min
  25. Spatial and temporal aspects of cellular calcium signals: 'elementary' signals and waves

  • Prof. Ian Parker
• 54 min
  26. Regulation of intracellular calcium signaling, localized signals and oscillations

  • Prof. Barbara Ehrlich
• 26 min
  27. Modeling Ca2+ signals

  • Dr. David Friel
• Calcium Effectors
• 34 min
  28. Neuronal calcium sensor proteins: calcium sensors and regulators of diverse cellular functions

  • Prof. Bob Burgoyne
• 41 min
  29. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization

  • Prof. Dermot Cooper
• 32 min
  30. Calcium and transcription-coupling

  • Dr. Karen Lounsbury
• 50 min
  31. Cellular calcium (Ca2+) buffers

  • Prof. Dr. Beat Schwaller
• 24 min
  32. Extracellular calcium signaling

  • Dr. Aldebaran M. Hofer
• 50 min
  33. Ca2+, fertilization and egg activation

  • Prof. Karl Swann
• 24 min
  34. Calcium regulation of transcription in plants

  • Prof. Hillel Fromm
• 34 min
  35. Mechanisms regulating STIM expression and function in Ca2+ signaling

  • Dr. Jonathan Soboloff
• 46 min
  36. Dynamic signal encoding in the S. cerevisiae calcium response

  • Dr. Chiraj Dalal
• Calcium and Disease
• 43 min
  37. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease

  • Prof. Laura del Senno
• 28 min
  38. Ca2+ alterations in familial Alzheimer's disease (FAD)

  • Dr. Paola Pizzo
• 38 min
  39. Pancreatitis and calcium signaling

  • Prof. Ole Petersen
• 47 min
  40. Mechanism-based therapies for heart failure and cardiac arrhythmias

  • Prof. Andrew Marks
• 46 min
  41. Genetic defects and calcium

  • Prof. Tullio Pozzan
• Archived Lectures *These may not cover the latest advances in the field
• 31 min
  42. Calcium, calmodulin and calcineurin

  • Prof. Stephen Bolsover
• 34 min
  43. Calcium flickers steer cell migration

  • Prof. Heping Cheng
• 28 min
  44. Automated Ca2+ imaging of chemosensory neurones in C.elegans

  • Dr. Nikos Chronis
• 46 min
  45. Ca2+ and the regulation of small GTPases

  • Prof. Peter Cullen
• 35 min
  46. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo

  • Dr. Michael I. Kotlikoff
• 35 min
  47. Capacitative (store-operated) calcium entry

  • Dr. Jim Putney

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Calmodulin sequences
3. Calmodulin structure - EF hands
4. EF hand proteins
5. Each calmodulin molecule binds four calcium ions
6. Calmodulin changes upon calcium binding
7. Cartoon of calmodulin binding calcium
8. Processes regulated by calmodulin
9. Classical activation of a target by Ca:calmodulin
10. Calmoduliun targets - 1-10 family
11. Calmoduliun targets - IP3
12. Calmoduliun targets - 1-14 family
13. Calmodulin activated Ca channel
14. Calmoduliun targets - 1-16 family
15. Full list of calmodulin targets
16. Lecture part 1: calmodulin and EF hand proteins
17. Calmodulin-dependent protein kinases
18. CaM kinase II
19. CaM kinase II is a multimeric enzyme
20. 2nd example of CaMKII activation
21. CaMKII shows 'molecular memory'
22. CaMKII and learning
23. Part 2: calmodulin dependent protein kinases
24. Calcineurin
25. Calcineurin - structure and function
26. Cyclosporin
27. Calcineurin involved in NFAT signaling pathway
28. Calcineurin specificity
29. PP1
30. Slingshot
31. Calcineurin activates downstream phosphatases
32. CaMKII vs. calcineurin - mild increase in Ca
33. CaMKII vs. calcineurin - intense increase in Ca
34. CaMKII vs. calcineurin - summary
35. Spatial and temporal affects combined
36. Lecture part 3: calcineurin
37. Summary of the lecture
38. Acknowledgements
39. References (1)
40. References (2)

Topics Covered

• Calmodulin is highly conserved
• Calmodulin structure
• EF hand proteins
• Calcium binding
• Calmodulin targets
• Mechanism of calmodulin action
• Calmodulin-dependent protein kinases
• Calmodulin dependent protein kinase II autonomy
• Calcineurin structure and activation
• Action of cyclosporin
• NFAT signaling
• Phosphatases downstream of calcineurin
• Differential responses of calmodulin-dependent protein kinase II and calcineurin to calcium signals

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on June 22, 2016

Financial Disclosures

• Prof. Stephen Bolsover has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.