We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Calmodulin sequences
- Calmodulin structure - EF hands
- EF hand proteins
- Each calmodulin molecule binds four calcium ions
- Calmodulin changes upon calcium binding
- Cartoon of calmodulin binding calcium
- Processes regulated by calmodulin
- Classical activation of a target by Ca:calmodulin
- Calmoduliun targets - 1-10 family
- Calmoduliun targets - IP3
- Calmoduliun targets - 1-14 family
- Calmodulin activated Ca channel
- Calmoduliun targets - 1-16 family
- Full list of calmodulin targets
- Lecture part 1: calmodulin and EF hand proteins
- Calmodulin-dependent protein kinases
- CaM kinase II
- CaM kinase II is a multimeric enzyme
- 2nd example of CaMKII activation
- CaMKII shows 'molecular memory'
- CaMKII and learning
- Part 2: calmodulin dependent protein kinases
- Calcineurin
- Calcineurin - structure and function
- Cyclosporin
- Calcineurin involved in NFAT signaling pathway
- Calcineurin specificity
- PP1
- Slingshot
- Calcineurin activates downstream phosphatases
- CaMKII vs. calcineurin - mild increase in Ca
- CaMKII vs. calcineurin - intense increase in Ca
- CaMKII vs. calcineurin - summary
- Spatial and temporal affects combined
- Lecture part 3: calcineurin
- Summary of the lecture
- Acknowledgements
- References (1)
- References (2)
Topics Covered
- Calmodulin is highly conserved
- Calmodulin structure
- EF hand proteins
- Calcium binding
- Calmodulin targets
- Mechanism of calmodulin action
- Calmodulin-dependent protein kinases
- Calmodulin dependent protein kinase II autonomy
- Calcineurin structure and activation
- Action of cyclosporin
- NFAT signaling
- Phosphatases downstream of calcineurin
- Differential responses of calmodulin-dependent protein kinase II and calcineurin to calcium signals
Talk Citation
Bolsover, S. (2007, October 1). Calcium, calmodulin and calcineurin [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/WVWX9319.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Stephen Bolsover has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.