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- Introduction to Calcium Signaling
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1. Introduction to cellular calcium signaling
- Dr. Martin Bootman
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2. Monitoring Ca2+ concentration in living cells
- Dr. Marisa Brini
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3. Cell boundary theorem
- Prof. Eduardo Ríos
- Calcium Influx
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4. Arachidonic acid and store-independent Ca2+ entry
- Dr. Luca Munaron
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5. Voltage-dependent calcium channels
- Prof. Annette Dolphin
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7. Intracellular Ca2+ signaling: calcium influx
- Prof. Anant Parekh
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8. Molecular identification of the CRAC channel
- Prof. Michael Cahalan
- Calcium Release
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10. The InsP3 receptor calcium release channel
- Prof. J. Kevin Foskett
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11. Molecular biology of ryanodine receptors: an overview
- Dr. Christopher George
- Prof. F. Anthony Lai
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12. cADPR and NAADP: messengers for calcium signalling
- Prof. Antony Galione
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13. Ryanodine receptors and cardiac function
- Prof. David Eisner
- Calcium Efflux and Sequestration
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14. Sodium-calcium exchange
- Prof. John Reeves
- Organelle Calcium
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15. Regulation and role of mitochondrial Ca2+ homeostasis
- Prof. Rosario Rizzuto
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16. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis
- Dr. Paola Pizzo
- Dr. Alex Costa
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17. Ca2+ dynamics between mitochondria and the endoplasmic reticulum
- Dr. Wolfgang Graier
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18. Nuclear calcium signaling
- Dr. Oleg Gerasimenko
- Dr. Julia Gerasimenko
- Spatiotemporal Calcium Signals
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19. Regulation of intracellular calcium signaling, localized signals and oscillations
- Prof. Barbara Ehrlich
- Calcium Effectors
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24. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization
- Prof. Dermot Cooper
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25. Calcium and transcription-coupling
- Dr. Karen Lounsbury
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26. Cellular calcium (Ca2+) buffers
- Prof. Dr. Beat Schwaller
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27. Extracellular calcium signaling
- Dr. Aldebaran M. Hofer
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28. Ca2+, fertilization and egg activation
- Prof. Karl Swann
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29. Calcium regulation of transcription in plants
- Prof. Hillel Fromm
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30. Mechanisms regulating STIM expression and function in Ca2+ signaling
- Dr. Jonathan Soboloff
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31. Dynamic signal encoding in the S. cerevisiae calcium response
- Dr. Chiraj Dalal
- Calcium and Disease
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32. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease
- Prof. Laura del Senno
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33. Ca2+ alterations in familial Alzheimer's disease (FAD)
- Dr. Paola Pizzo
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34. Pancreatitis and calcium signaling
- Prof. Ole Petersen
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35. Mechanism-based therapies for heart failure and cardiac arrhythmias
- Prof. Andrew Marks
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36. Genetic defects and calcium
- Prof. Tullio Pozzan
- Archived Lectures *These may not cover the latest advances in the field
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37. Calcium, calmodulin and calcineurin
- Prof. Stephen Bolsover
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38. Calcium flickers steer cell migration
- Prof. Heping Cheng
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39. Automated Ca2+ imaging of chemosensory neurones in C.elegans
- Dr. Nikos Chronis
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40. Ca2+ and the regulation of small GTPases
- Prof. Peter Cullen
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41. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo
- Dr. Michael I. Kotlikoff
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42. Capacitative (store-operated) calcium entry
- Dr. Jim Putney
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43. The molecular biology of the inositol trisphosphate receptor
- Dr. Randen Patterson
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44. Coordinated Ca2+ release from intracellular Ca2+ stores
- Prof. Ole Petersen
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45. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology
- Prof. Ernesto Carafoli
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46. The calcium saga: a matter of life and death
- Prof. Pierluigi Nicotera
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47. Ca2+ efflux and Ca2+ signals
- Dr. Anne Green
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50. Modeling Ca2+ signals
- Dr. David Friel
Printable Handouts
Navigable Slide Index
- Introduction
- Outline of lecture
- What are Ca waves and oscillations?
- Ca waves
- Ca oscillations
- Ca transients encodes important information
- Changes in intracellular Ca signaling
- Introduction to Ca signaling
- What is needed for intracellular Ca signaling?
- InsP3R type I in the cerebellar purkinje cells
- InsP3R: three isoforms and three domains
- InsP3R: a large protein that makes an ion channel
- InsP3R production is required
- The InsP3 dependence varies among isoforms
- Ca dependence of the InsP3R isoforms
- Signal initiation in dendrites
- Chromagranin A and B bind to the InsP3R
- Ca/InsP3R regulate channel activity
- Effect of chromagranin B on InsP3R activity
- CGB fragment alters InsP3R channel function
- CGB fragment alters Ca release in PC12 cells
- The localization of CGB is not uniform in cells
- Many other proteins are uniformly distributed
- The functional coupling of CGB to the InsP3R
- CGB localization in hippocampus rat cells
- Disease-related changes in Ca signaling
- Conclusions: InsP3R and chromogranin
- Signal initiation in the cytoplasm
- Testosterone induced Ca oscillations
- The importance of buffers
- Ca buffers expression in specific regions of the cell
- Testosterone induced Ca oscillations
- Testosterone induced neurite outgrowth
- High testosterone decreases cell viability
- High testosterone changes the calcium signal
- Conclusions: InsP3R and testosterone
- Regulation of oscillations
- SHP-2: SH2 domain-containing PTP
- SHP-2 positively regulates RTK pathways
- SHP-2 is required for FGF-induced Ca oscillations
- Noonan's syndrome
- NS-SHP-2 mutation enhances Ca oscillation
- SHP2 modulates Ca oscillation in cardiac myocyte
- Frequency of Ca oscillations and NFAT activity
- Conclusions InsP3R and SHP-2
- Conclusions
- Collaborators
Topics Covered
- Calcium as a trigger for many cellular events including muscle contraction, hormone secretion and cell growth
- The release of calcium from intracellular stores using electrophysiological, biochemical and molecular techniques combined with imaging
- Regulation by chromogranin, a protein that binds to the major calcium release channel, the InsP3R
- Regulation by a steroid hormone both at physiological and supra-physiological levels
- Regulation by a protein tyrosine phosphatase SHP-2
- The consequences of mutations or non-physiological modulations of each pathway
Talk Citation
Ehrlich, B. (2007, October 1). Regulation of intracellular calcium signaling, localized signals and oscillations [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 12, 2024, from https://doi.org/10.69645/RSGR4973.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Barbara Ehrlich has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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