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Printable Handouts
Navigable Slide Index
- Introduction
- History
- History - calcium is essential to sustain heartbeat
- Calcium and cytotoxicity
- Arsenazo III
- Calcium accumulation and cell death
- Effect of oxidative stress on calcium storage
- Effect of oxidative stress on calcium extrusion
- Downstream effectors of calcium toxicity
- The calcium and thiol hypothesis of cell death
- The inositolphosphate pathway and calcium
- Calcium signaling as target of chemical toxicity
- Ca2+ is involved in different cell death paradigms
- The discovery of regulated nuclear Ca2+ transport
- Ca2+ - activated degradative processes
- Intracellular Ca2+ distribution in living cells
- Ca2+ and phosphatidylserines exposure
- Plasma membrane calcium pumps (PMCAs)
- Cleavage of PMCA2 in apoptosis
- hPMCA4 is cleaved and inactivated by caspases
- Mutation of caspase-3 cleavage site on hPMCA4
- hPMCA4 localization and its loss on apopatosis
- PMCA4 transfection restores calcium handling
- PMCA mutants protect against cell death
- Conserved death mechanisms
- Ca2+ deregulation and neuronal death
- Ca2+ deregulation in excitotoxic death
- NCX3 cleavage by calpains and Ca2+ overload
- NCX mutants and Ca2+ overload
- NCX3 siRNA amplifies death signals
- Effect of non-cleavable NCX on excitotoxicity
- Common features in cell death pathways
- Conclusion: role of calcium in cell death
Topics Covered
- Calcium and cytotoxicity
- Indicator dyes for calcium detection
- Alteration of thiol and calcium homeostasis causes cell death
- Oxidative stress and thiol modification impair calcium storage and extrusion
- Calcium ATPase
- The calcium and thiol hypothesis of cell death
- Calcium as a second messenger
- Calcium is involved in different cell death paradigms
- Nuclear calcium transport
- Intracellular calcium distribution
- PMCAs: vital membrane calcium transporters
- PMCAs are degraded during cell death
- Non-degradable PMCAs protect against cell death
- Mechanisms of calcium deregulation during cell death
- NCX3 and calpains in calcium maintenance
- Prevention of excitotoxicity via calcium management
Talk Citation
Nicotera, P. (2007, October 1). The calcium saga: a matter of life and death [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/ODQS4282.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Pierluigi Nicotera has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.