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1. Introduction to biochemistry
- Prof. Gerald W. Feigenson
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2. Amino acids and peptides
- Prof. Gerald W. Feigenson
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3. Protein structure principles
- Prof. Gerald W. Feigenson
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4. Observed protein structures
- Prof. Gerald W. Feigenson
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5. Protein folds and IV structure
- Prof. Gerald W. Feigenson
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6. Protein stability and folding
- Prof. Gerald W. Feigenson
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7. Haemoglobin structure and stability
- Prof. Gerald W. Feigenson
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8. Enzyme specificity and catalysis
- Prof. Gerald W. Feigenson
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9. Enzyme kinetics (Michaelis-Menten)
- Prof. Gerald W. Feigenson
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10. Enzyme inhibition; chymotrypsin
- Prof. Gerald W. Feigenson
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11. Enzyme regulation and coenzymes
- Prof. Gerald W. Feigenson
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12. Lipids, biomembranes and membrane proteins
- Prof. Gerald W. Feigenson
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13. Structure and function of carbohydrates
- Prof. Gerald W. Feigenson
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14. Metabolism principles
- Prof. Gerald W. Feigenson
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15. Glycolysis - energy and useful cell chemicals
- Prof. Gerald W. Feigenson
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16. Glycolysis control
- Prof. Gerald W. Feigenson
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17. Metabolism of pyruvate and fat
- Prof. Gerald W. Feigenson
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18. Urea cycle; oxidative phosphorylation 1
- Prof. Gerald W. Feigenson
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19. Urea cycle; oxidative phosphorylation 2
- Prof. Gerald W. Feigenson
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20. Light-driven reactions in photosynthesis
- Prof. Gerald W. Feigenson
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21. Gluconeogenesis and the Calvin cycle
- Prof. Gerald W. Feigenson
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22. Synthesis of lipids and N-containing molecules 1
- Prof. Gerald W. Feigenson
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23. Synthesis of lipids and N-containing molecules 2
- Prof. Gerald W. Feigenson
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24. Hormone mechanisms
- Prof. Gerald W. Feigenson
Printable Handouts
Navigable Slide Index
- Introduction
- Lecture outline
- An overview of metabolism for this course
- Complexity of metabolism: galactose utilisation
- Glycolysis: connections to other metabolism
- A few words about monosaccharides
- Glycolysis: the basics
- How cells use glycolysis (1)
- DHAP is connected to nucleotide synthesis
- DHAP is connected to lipid synthesis
- How cells use glycolysis (2)
- Overall 'strategy' and mechanism of glycolysis
- Bond-cleaving 'strategy'
- Glycolysis part 1
- Glycolysis part 2
- Glycolysis reaction conditions inside the cell
- Mechanism of GAPDH
- Lecture summary
Topics Covered
- Overview of metabolism
- Interconnections of glycolysis and other metabolisms
- Glycolysis in detail
Links
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Talk Citation
Feigenson, G.W. (2022, November 27). Glycolysis - energy and useful cell chemicals [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/FUNX4269.Export Citation (RIS)
Publication History
Financial Disclosures
- Gerald Feigenson has no commercial/financial relationships to disclose.
Request access to the Principles of Biochemistry lecture series, an extensive introductory to the field of biochemistry. An HSTalks representative will contact you with more information about this series and getting unrestricted access to it.
A selection of talks on Cardiovascular & Metabolic
Transcript
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0:00
Greetings. Welcome to this lecture 15 in this Principles of Biochemistry lecture series.
I am Jerry Feigenson,
a professor in the Department of Molecular Biology and Genetics
at Cornell University in the USA.
In the 14th lecture,
you learned some key principles of metabolism energetics,
and more are coming in the future lectures.
You saw in the 14th lecture,
how to think about the stability of molecules,
and in particular, what are high-energy molecules,
and whether reactions tend to occur?
You saw that redox reactions have
an especially important role for all creatures that require oxygen for life.
0:55
In this 15th lecture,
you will see how thousands of chemical reactions of metabolism are interconnected,
and we only have very partial knowledge about that.
You will see why cells rely on stored glucose as their energy source.
And glycolysis provides, besides energy,
many useful chemicals for the cell.
We will see the strategy of isomerisation and carbon-carbon bond cleavage in glycolysis.
We will see that Delta G, as opposed to Delta G_0,
Delta G is used to identify
which reaction steps in metabolism are far from equilibrium and regulated.
Then at the end we will see the reaction steps in one enzyme of glycolysis,
glyceraldehyde 3-phosphate, this is the only redox step of glycolysis.