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Lipids, biomembranes and membrane proteins

Published on April 19, 2020 Reviewed on November 27, 2022   41 min

Request access to the Principles of Biochemistry lecture series, an extensive introductory to the field of biochemistry. An HSTalks representative will contact you with more information about this series and getting unrestricted access to it.

A selection of talks on Biochemistry

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Greetings. Welcome to this Principles of Biochemistry lecture series. I am Jerry Feigenson. I am a professor in the Department of Molecular Biology & Genetics at Cornell University in the USA. In the 11th lecture, you saw that many proteins need non-amino acid components, such as small molecules and ions in order to perform the wide range of biochemical catalysis. Then, we examined how enzymes can be controlled, either by controlling their concentration or by controlling their catalytic activity. We looked at two examples of activity control in detail, allosteric control of ATCase and peptide bond cleavage to create active chymotrypsin. In this 12th lecture,
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you will learn that biomembrane components are mainly 2-chain phospholipids, sterols like cholesterol, and membrane proteins. You will see that biomembranes can have interesting phase behaviors and I will introduce you to phospholipase enzymes that catalyze lipid breakdown, creating different chemicals used by the cell. You will see that proteins are anchored to the membrane in six particular ways. Finally, you will see that membrane fusion occurs and is under control.

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