Lipids, biomembranes and membrane proteins

Published on April 19, 2020 Reviewed on November 27, 2022   41 min

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A selection of talks on Biochemistry

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Greetings. Welcome to this Principles of Biochemistry lecture series. I'm Jerry Feigenson. I'm a professor in the Department of Molecular Biology and Genetics at Cornell University in the USA. In the 11th lecture, you saw that many proteins need non amino acid components, such as small molecules and ions, in order to perform the wide range of biochemical catalysis. Then we examined how enzymes can be controlled, either by controlling their concentration or by controlling their catalytic activity. We looked at two examples of activity control in detail: allosteric control of ATCase and peptide bond cleavage to create active chymotrypsin.
In this 12th lecture, you will learn that biomembrane components are mainly two chain phospholipids, sterols like cholesterol, and membrane proteins. You will see that biomembranes can have interesting phase behaviors. And I will introduce you to phospholipase enzymes that catalyze lipid breakdown, creating different chemicals used by the cell. You will see that proteins are anchored to the membrane in six particular ways. Finally, you will see that membrane fusion occurs and is under control.