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1. Introduction
2. The systolic Ca transient
3. RyR and Ca induced Ca release from the SR
4. What controls the size of the Ca transient?
5. What produces stability of SR and systolic Ca?
6. Quantifying SR Ca content in cardiac myocytes
7. Sarcolemmal Ca entry = exit
8. How is SR content controlled?
9. Measuring cytoplasmic calcium concentration
10. SR Ca content controls sarcolemmal fluxes
11. Control of Ca entry and efflux by Ca transient
12. Does RyR modulatrion alter cardiac contractility?
13. Effects of RyR potentiating with caffeine
14. Ca and arrhythmias
15. Can't increase SR Ca beyond a certain threshold
16. Ca waves are arrhythmogenic
17. Mutations in the RyR - arrhythmias
18. Selective removing of arrhythmias
19. Depressing RyR opening with tetracaine
20. Pulsus alternans
21. Alternans due to excessive feedback control
22. Excessive feedback gain
23. Two experimental models of alternans
24. Does SR content alternate?
25. Alternans accompanied by SR content alternans
26. Confocal linescans in control
27. Steep dependence of Ca release on SR content
28. Similar waves seen with acidosis or tetracaine
29. Ca waves during alternans
30. Working model: changes of SR Ca - alternans
31. Working model summary cartoon (1)
32. Working model summary cartoon (2)
33. Summary
34. Acknowledgements

Topics Covered

• Introduction to Calcium cycling in the heart
• How to measure SR and sarcolemmal Calcium fluxes
• What controls SR Calcium content
• The effects of changing the open probability of the RyR
• The link between Calcium and arrhythmias
• Mechanisms responsible for alternans in the heart

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. David Eisner has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.