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1. Introduction to biochemistry
- Prof. Gerald W. Feigenson
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2. Amino acids and peptides
- Prof. Gerald W. Feigenson
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3. Protein structure principles
- Prof. Gerald W. Feigenson
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4. Observed protein structures
- Prof. Gerald W. Feigenson
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5. Protein folds and IV structure
- Prof. Gerald W. Feigenson
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6. Protein stability and folding
- Prof. Gerald W. Feigenson
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7. Haemoglobin structure and stability
- Prof. Gerald W. Feigenson
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8. Enzyme specificity and catalysis
- Prof. Gerald W. Feigenson
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9. Enzyme kinetics (Michaelis-Menten)
- Prof. Gerald W. Feigenson
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10. Enzyme inhibition; chymotrypsin
- Prof. Gerald W. Feigenson
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11. Enzyme regulation and coenzymes
- Prof. Gerald W. Feigenson
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12. Lipids, biomembranes and membrane proteins
- Prof. Gerald W. Feigenson
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13. Structure and function of carbohydrates
- Prof. Gerald W. Feigenson
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14. Metabolism principles
- Prof. Gerald W. Feigenson
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15. Glycolysis - energy and useful cell chemicals
- Prof. Gerald W. Feigenson
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16. Glycolysis control
- Prof. Gerald W. Feigenson
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17. Metabolism of pyruvate and fat
- Prof. Gerald W. Feigenson
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18. Urea cycle; oxidative phosphorylation 1
- Prof. Gerald W. Feigenson
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19. Urea cycle; oxidative phosphorylation 2
- Prof. Gerald W. Feigenson
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20. Light-driven reactions in photosynthesis
- Prof. Gerald W. Feigenson
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21. Gluconeogenesis and the Calvin cycle
- Prof. Gerald W. Feigenson
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22. Synthesis of lipids and N-containing molecules 1
- Prof. Gerald W. Feigenson
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23. Synthesis of lipids and N-containing molecules 2
- Prof. Gerald W. Feigenson
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24. Hormone mechanisms
- Prof. Gerald W. Feigenson
Printable Handouts
Navigable Slide Index
- Introduction
- Prior knowledge I
- Prior knowledge II
- Key to biochemistry: all parts are interconnected
- The metabolism discussed in this course
- Distribution of matter in the universe
- Patterns occur at all size scales
- Patterns at ever smaller scales
- How did chemistry begin?
- A few important nuclear reactions in star cores
- Chemistry as we know it
- Life as we know it
- Properties of living systems
- Limited variety of compounds & reactions in life
- Many interconnections
- Metabolism connected to glucose
- Only partial knowledge of metabolism
- Different molecules & ions enter and leave the cell
- How do enzymes work? Example
- Goals of the first few lectures of this course
- What do we want to understand about proteins?
- Amino acids
- Ion pairs hold haemoglobin together
- Protonation of ionisable groups and the pH
- What to learn by using the H - H equation
- Simple rules to remember
- Lecture summary
Topics Covered
- Matter in the universe
- Origin of chemistry
- Nuclear reactions
- Properties of living systems
- Main biomolecules
- Metabolism generalities
- Importance of enzymes
- Amino acid residues
- Ionisable groups
Talk Citation
Feigenson, G.W. (2022, November 27). Introduction to biochemistry [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/YJOV3816.Export Citation (RIS)
Publication History
Financial Disclosures
- Gerald Feigenson has no commercial/financial relationships to disclose.
Request access to the Principles of Biochemistry lecture series, an extensive introductory to the field of biochemistry. An HSTalks representative will contact you with more information about this series and getting unrestricted access to it.
A selection of talks on Biochemistry
Transcript
Please wait while the transcript is being prepared...
0:00
Greetings. Welcome to this Principles of Biochemistry lecture series.
I am Jerry Feigenson.
I am a professor in the Department of
Molecular Biology and Genetics at Cornell University in the USA.
These biochemistry lectures cover a wide range of topics.
A student or viewer might want to refer to
the presentation that lists all the lecture topics to be covered in this series.
0:29
I assume some prior knowledge of chemical principles.
For example, a year of general chemistry that should provide you with
some knowledge of acid-base chemistry and some very basic thermodynamics.
Although, when we get to thermodynamics,
I will discuss each principle.
0:49
One semester of organic chemistry will also be useful.
For example, we discuss functional groups,
alcohols, aldehydes, carboxyls as shown here.
When we get to enzyme mechanisms,
we will use the arrow pushing that shows the electron flows.
We will discuss chemical bonding, stereochemistry and resonance.
Some knowledge of general biology will be useful.
Not so much is required, for example,
remind yourself of the structure of eukaryotic cells.
1:23
A key to biochemistry is that all the parts are interconnected.
For example, four main classes of biomolecules, proteins,
RNA and DNA, carbohydrates,
lipids and membranes, they're all connected to each other.
We will study these individually.
We will study proteins,
we'll look at their structure,
how proteins can signal RNA and DNA.
We will hardly talk about RNA and DNA in this course.
We will save those for a separate course on molecular biology.
Carbohydrates. We'll talk about carbohydrates, their structures,
their synthesis, and some of their reactions and metabolism.
Membranes and lipids.
We will look at lipid structures and lipid phases and their chemical reactions.
Those are four classes of biomolecules.
In addition to those, in biochemistry,
we see a very large number of chemical reactions and they're all interconnected.
Shown here is a chart that shows connections among about 500 different small molecules.
In fact, in a real cell,
there are 10 times this number,
about 5,000 chemical reactions,
and they're all interconnected.
Interconnected, what's the mechanism of interconnection?
Protein-protein interactions, protein-membrane interactions,
protein-small molecule metabolite interactions,
and protein-DNA and RNA interactions.