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1. Introduction
2. The IP3 receptor
3. Types of the IP3-R throughout the evolution
4. mRNA isomers through the development
5. Expansion of a gene: importance of function
6. IP3-R isoforms potentially exist
7. The expression of the IP3-R throughtout the cell
8. Different IP3-R paralogs have different distributions
9. Organelles in the cell
10. IP3-R identified in the ER
11. The IP3-R model
12. Ankrin regulates channel activity and stability
13. Chromagranins (Cg): Ca binding proteins
14. The physiological link between the IP3-R and Cg
15. Cg has an inhibitory effect on IP3-R function
16. ERP44:IP3-R interaction
17. Conditions in which ERP44 regulates IP3-R
18. Proteins interaction with IP3-R lumenar regions
19. CAM binding peptides
20. CaBPs (calbindin): neuronal EF hand
21. CaBPs interact with IP3-R
22. RACK1 and the heterotrimeric G protein
23. IP3-R:RACK1 interaction
24. Human B-cells C825T mutation for G-beta-3
25. IRBIT binds IP3-R near the IP3-R binding pocket
26. IRBIT is sensitive to the IP3-R binding IP3
27. Proteins interact with IP3-R: myosin, IRAG, CARP
28. Myosin: IP3R modulate pharyngeal pumping
29. CARP: carbonic anhydrase-related protein
30. CARP binding sites in the IP3-R
31. IRAG: IP3-R associated cyclic GMP kinase
32. CGK1-beta
33. The C-terminus of IP3-R
34. Ca induced apoptosis and huntigton
35. PP1A regulates IP3-R phosphorylation by PKA
36. Mechanism for alterations: IP3-R phosphorylation
37. IP3-R as a cytoskeletal element
38. The 4.1N is critical for the basal-lateral targeting
39. A multitude functional proteins interact with IP3-R
40. IP3R in the Golgi apparatus
41. Cg, Cam and CaBPs interact with IP3-R
42. Sec 6/8 are active upstream of IP3 binding site
43. IP3-R and plasma membrane interaction
44. TRPC channels: Homer, Bank and Junctate
45. The model for IP3R-TRPC interactions
46. An Inhibitory effect of TRPC on IP3-R
47. Are TRPC channels coupled to the IP3-R?
48. The role of IP3-R in the TRPC activation
49. Junctate protein interacts with IP3-R
50. Junctate stimulates Ca release
51. Proteins involved in the IP3R-TRPC complex
52. BANK protein activity
53. Proper Ca signaling
54. IP3R affects the mitochondrial Ca homeostasis
55. Apoptotic and nonapoptotic proteins
56. IP3R is juxtaposed to mitochondria
57. Ca overload is the key to cytochrome C release
58. Caspase 3 and calpein in apoptosis
59. Bcl and Bcl-xl: anti-apoptotic proteins
60. Proteins interact with IP3-R during apoptosis
61. The nucleus
62. Nuclear Ca signals are induced by hepatocytic GF
63. Why is IP3R located in the nucleus?
64. IP3R in calciosomes
65. Calciosomes
66. Why are there 23,001 isomers of IP3R?
67. IP3R isomers are necessary for function specificity
68. Conclusions

Topics Covered

• Activation of the IP3-receptor (IP3R), a major endoplasmic Calcium release channel in many cells, is activated by the second messenger inositol 1,4,5-trisphosphate (IP3)
• The IP3R is unique in that it can integrate signals from numerous cellular pathways via a myriad of inputs which include nucleotide binding, phosphorylation, Calcium binding and protein-protein interactions
• A diverse range of cellular functions are modulated by the IP3R including contraction/excitation, secretion, gene expression, cell cycle, apoptosis and cellular growth
• The nodal properties of the IP3R and the mechanisms by which this occurs

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Patterson, R. (2007, October 1). The molecular biology of the inositol trisphosphate receptor [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/DOFE8213.
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Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Dr. Randen Patterson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.