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1. Introduction
2. Properties of voltage-activated calcium channels
3. Voltage clamp of Ca currents
4. Why is the IV plot for calcium currents U shaped?
5. Tail currents (1)
6. Tail currents (2)
7. Physiological sequence during tansmitter release
8. alpha-1 subunit of the channel
9. Voltage sensor
10. Domain I of alpha1B subunit (rabbit)
11. Ca selectivity
12. Role of glutamate residue in Ca selectivity (1)
13. Role of glutamate residue in Ca selectivity (2)
14. Permeation
15. Calcium channel classes
16. Calcium channel pharmacology (1)
17. Calcium channel pharmacology (2)
18. Structure of omega-conotoxins
19. Calcium channel pharmacology
20. Some functions of alpha-1 subunits
21. Auxiliary subunits enhance current
22. Beta subunit of the channel
23. Beta subunit is required to target alpha-1
24. Effects of beta and alpha-2-deltha on Ca currents
25. Roles of Ca channel alpha-2-deltha subunits (1)
26. Roles of Ca channel alpha-2-deltha subunits (2)
27. Alpha2deltha effect on voltage-gated Ca currents
28. Alpha2deltha effect on voltage-gated Ca currents
29. Roles of calcium channel gamma subunits
30. Calcium channel classes
31. GABA agonist baclofen
32. Inhibitory modulation of calcium channels
33. Ca channels are subject to G protein modulation
34. G protein regulation of Ca channels (1)
35. G protein regulation of Ca channels (2)
36. Evidence modulation by G-beta-gamma
37. Channelopathies associated with alpha-1 subunits
38. Hypokalaemic periodic paralysis
39. Episodic ataxia-2 mutations
40. Spinocerebellar ataxia-6
41. Familial hemiplegic migraine
42. Mouse mutants with SWD and cerebellar ataxia
43. Structure of voltage-dependent calcium channels

Topics Covered

• Introduction to voltage-gated calcium channels
• Correlation of known structural features to function
• Subtypes of calcium channels and their physiological correlates
• Pharmacology of voltage-gated calcium channels
• G protein modulation of certain subtypes of voltage-gated calcium channels
• Calcium channelopathies

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Annette Dolphin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.