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Printable Handouts
Navigable Slide Index
- Introduction
- Agonist-activated calcium entry
- Store vs. non-store operated calcium channels
- Arachidonic acid (AA) metabolism
- Identity of AA-activated calcium channels
- The first Arachidonic acid model
- Angiogenesis and calcium signaling
- Proangiogenic factor bFGF triggers calcium entry
- Activation of tyrosine kinase receptors - effects
- Proangiogenic calcium entry is mediated by AA
- Different channels are involved in calcium entry
- The Arachidonic acid model in endothelial cells
- Nitric oxide
- Nitric oxide's role in proangiogenic calcium entry
- AA, NO release and calcium entry relations
- The Arachidonic acid model is more complex
- Biological roles of AA-activated calcium entry
- AA- & NO-induced Ca2+ entry affects proliferation
- CAI is an antiangiogenic compound in vivo
- AA and tumor angiogenesis
- ECs derived from human breast carcinoma (BTEC)
- AA promotes BTEC tubulogenesis in vitro
- CAI reduces AA-induced BTECs tubulogenesis
- BTEC organization in capillary-like structures
- Multiple roles for protein kinase A (PKA)
- In BTECs NO is involved in calcium signaling
- Another increase in signaling complexity
- Differences between normal & tumor-derived ECs
- Conclusions
- Open questions
- Laboratory of cellular and molecular angiogenesis
Topics Covered
- Agonist-activated calcium entry: different modes
- Synthesis and metabolism of arachidonic acid (AA)
- Properties of AA-activated calcium channels
- Other effects of AA on calcium homeostasis
- Calcium entry and cell proliferation
- AA as a critical mediator of mitogen-activated calcium entry in fibroblasts
- Role of AA-dependent calcium entry in endothelial cell proliferation and angiogenesis
- Nitric oxide, calcium entry and angiogenesis
- Regulation of proangiogenic calcium signals: a complex picture
Talk Citation
Munaron, L. (2011, August 16). Arachidonic acid and store-independent Ca2+ entry [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/ILEE6165.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Luca Munaron has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.