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- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
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2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
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4. The SODs
- Prof. Daret St. Clair
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5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
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6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
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7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
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8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
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9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
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11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
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12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
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13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
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14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
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15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
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16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
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17. Oxidative stress in aging
- Dr. Jose Vina
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18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
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19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
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20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
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21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
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22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
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24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Essential antioxidants
- Daily intake of essential antioxidants
- Polyphenols have antioxidant properties
- Free radicals and immune cell function
- Animals' response to different pathogens
- Antioxidant defenses in immune infection
- Inflammatory periodontitis and serum antioxidants
- Vitamin E content of blood composition
- Antioxidants-host defense-infection interaction (1)
- Vitamin E deficiency and the immune responses
- Vitamin E deficiency and human immune response
- Numerous CVB3 variants exist
- Experiment by Beck et al.
- Beck's study design
- Nucleotide and amino acid changes
- Beck's experiment's findings
- Antioxidants-host defense-infection interaction (2)
- Infectious diseases in the elderly
- Effect of host age on CVB3 virulence
- T cell mediated immune function
- Effect of host on CVB3 virulence
- Virus origin effect on recipient young mice survival
- Virus origin effect on young mice heart pathology
- Effect of passage through an old vs. young host
- Antioxidant supplementation (1)
- Vitamin E and immune response in the aged
- Blood vitamin E levels and change in DTH
- Antioxidant supplementation (2)
- Vitamin E decreases mice lung influenza viral titer
- Effect of micronutrient supplement on DTH
- Antioxidant supplementation (3)
- Resveratrol and curcumin effect on T cells
- Clinical benefit from antioxidant supplementation?
- Experimental design
- Primary outcomes in the study
- Secondary outcomes in the study
- Study profile
- Vitamin E supplementation and plasma vitamin E
- Effect of vitamin E on respiratory infections
- Effect of vitamin E on common colds
- Vitamin E status and pneumonia
- Study conclusion
- Study implications
- Serum Zn levels and pneumonia in elderly
- Effect of zinc supplementation on infection
- Zn supplementation and oxidative stress markers
- Effect of Se supplementation on poliovirus
- Selenium and immune response and infection
- Serum Se in healthy subjects and HIV patients
- How do antioxidants exert their effect?
- Vitamin E-induced T cell function enhancement
- Age and vitamin E effects on naive T cells
- Effect of vitamin E on gene expression
- T cell activation
- Hypothesis
- Experiment 1: in vitro study design
- Detecting effective immune synapses formation
- Vitamin E effect on immune synapse formation (1)
- Vitamin E effect on immune synapse formation (2)
- Summary
- Antioxidants and immune response
- Acknowledgements (1)
- Acknowledgements (2)
- Acknowledgements (3)
Topics Covered
- Essential antioxidants
- Antioxidant defenses in immune infection
- Antioxidants-host defense-infection: a complex interaction
- Vitamin E deficiency
- CVB3
- Effect of host age
- Effect of virus origin
- Effect of passage
- Antioxidant supplementation
- Vitamin E and immune response in the aged
- Not all antioxidants behave the same
- Clinical benefits from antioxidant supplementation
- Zinc supplementation
- Selenium
- How do antioxidants exert their effect?
- T-cell function
Links
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Talk Citation
Meydani, S. (2007, November 1). Antioxidants and immune response and infectious diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/396/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Simin Meydani has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.