Adhesion GPCRs in nervous system development and disease

Published on May 16, 2019   36 min

Other Talks in the Category: Biochemistry

0:00
Hello, everybody, my name is Tobias Langenham, and I'm a professor of Biochemistry, at the Rudolf Schönheimer Institute of Biochemistry at Leipzig University in Germany. Today, I'd like to introduce "Adhesion G-Protein-Coupled-Receptors, and their Multiple Roles in Nervous System Development and Disease".
0:22
First, I would like to introduce the superfamily of G-protein-coupled receptors. The surface molecules are mounted on the edges of many cells in our bodies, and they amount to a massive battery of genes stored in the genomes of actually all animals including humans. For example, the human genome amounts and accounts more than 700 different GPCR genes. GPCRs are implicated in multiple positions within our bodily functions. For example, sensory systems that allow us to smell compounds or to see things through our eyes. They are also involved into feedback loops that are controlled, for example, by hormones. The GPCR superfamily can be divided according to different classification schemes. In the slide, you can see a subdivision that is very popular, which is termed GRAFS classification.
1:27
The GRAFS classification divides the GPCR superfamily into five different classes.
1:35
That is, the Glutamate receptors, Rhodopsin- like receptors, Adhesion GPCRs, Frizzled/Taste2 receptors, Secretin receptors. These different families within this GPCR superfamily contain different numbers of genes. As you can see, rhodopsin-like GPCRs by far outnumber all the other GPCR families with over 600 different genes. However, the next largest group is adhesion GPCRs that are depicted here in the middle, with over 30 different genes in the mammalian genomes. In the slide, you can see some of the structural hallmarks that are
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Adhesion GPCRs in nervous system development and disease

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