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- Epidemiology and Risk Factors
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1. The changing prevalence of asthma
- Dr. Deborah Jarvis
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2. Recent advances in asthma genetics
- Prof. Miriam Moffatt
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3. Asthma: an epidemic caused by epigenetics?
- Prof. David Schwartz
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4. Role of the microbiota in asthma
- Prof. B. Brett Finlay
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5. Diet and asthma
- Prof. Lewis Smith
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6. Obesity and asthma
- Prof. Anne Dixon
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7. Occupational asthma: management beyond the textbooks
- Prof. Paul Cullinan
- Clinical Phenotypes
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8. The origins of asthma
- Prof. Peter Sly
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9. Pre-school wheeze
- Prof. Andrew Bush
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11. Smoking asthmatics
- Prof. Neil Thomson
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12. Aspirin exacerbated respiratory disease
- Prof. Chris Corrigan
- Mechanisms of Asthma
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13. Advances in asthma: airway inflammation
- Prof. William Busse
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14. The role of mast cells in asthma
- Prof. Peter Bradding
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15. Dendritic cells in asthma
- Prof. Bart Lambrecht
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16. The airway smooth muscle in asthma
- Prof. Judith Black
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17. Role of virus infection in asthma 1
- Prof. Sebastian Johnston
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18. Role of virus infection in asthma 2
- Prof. Sebastian Johnston
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19. Severe asthma: characterisation, mechanisms & treatment
- Prof. Fan Chung
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20. Steroid resistance in asthma: mechanisms and potential therapies
- Prof. Ian Adcock
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21. Macrophage in asthma
- Prof. Douglas Robinson
- Diagnosis of Asthma
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22. Physiology of asthma and involvement of small airways
- Prof. Charles G. Irvin
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23. Induced sputum in asthma
- Prof. Antonio Spanevello
- Therapy and Management
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25. Pulmonary drug delivery
- Prof. Anthony J. Hickey
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26. The management of chronic asthma
- Prof. Mark Fitzgerald
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27. Inhaled corticosteroids and beta2-agonists
- Dr. Omar S. Usmani
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28. Management of "difficult asthma"
- Prof. Elisabeth Bel
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29. Management of acute exacerbations of asthma
- Dr. Chris Fanta
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30. Non-pharmacological treatments for asthma
- Prof. Neil Thomson
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31. Asthma: beyond the prescription
- Prof. Martyn Partridge
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32. New drugs for asthma
- Prof. Peter Barnes
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33. Anti-IgE therapy for asthma
- Dr. Andrew Menzies-Gow
- Archived Lectures *These may not cover the latest advances in the field
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34. New drugs for asthma
- Prof. Peter Barnes
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35. Asthma phenotypes in children
- Prof. Andrew Bush
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36. Steroid resistance in asthma: mechanisms and potential therapies
- Prof. Ian Adcock
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37. Severe asthma in children
- Prof. Andrew Bush
Printable Handouts
Navigable Slide Index
- Introduction
- COI statement
- Presentation aims
- Pre-school wheeze (1)
- Coughs and wheezes
- All that wheezes is not asthma
- Upper airway disease: what is normal?
- Normal childhood respiratory symptoms
- Asthma misdiagnosis
- Persistent bacterial bronchitis
- What caused the symptoms?
- What caused the symptoms? - Foreign body
- Atopic wheezer: which side normal?
- Well term baby
- Modern CT scan
- Persistent symptoms after neonatal RDS
- Additional cases
- Persistent asthma
- Points in the history
- Physical examination
- Pre-school wheeze (2)
- Symptom patterns
- What about pathology?
- An overview of important events
- Something can be done
- Episodic viral wheeze & multiple trigger wheeze
- Pre-school wheeze (3)
- After asthma: redefining airways diseases
- What is this thing called asthma? (1)
- Deconstructing the airway
- What is this thing called asthma? (2)
- Pre-school wheeze: make measurements
- Spirometry
- Pre-school spirometry: new data
- Induced sputum
- IS and inflammation/airway disease
- Pre-school wheeze (4) & indications for treatment
- ICS are not disease modifying
- Disease modifying therapies
- Monteleukast: old and new
- The A word: antibiotics
- Azithromycin
- AZM to prevent progression
- Third time unlucky
- The role of ICS
- ICS: what have we learned?
- Is it asthma Dr? A meaningless question (1)
- Is it asthma Dr? A meaningless question (2)
- How would this work in practice?
- Personalised medicine
- Prednisolone
- Episodic (viral) wheeze: the role of Prednisolone
- Episodic treatment for episodic problems
- Therapeutic trial in MTW
- Pre-school wheeze (5)
- Take home messages
- Thanks for listening
Topics Covered
- The differential diagnosis for pre-school children with wheeze
- The pathophysiology of pre-school wheeze
- Different measurement tools for use in the clinic to assess pre-school wheeze
- Variety of treatment options available for pre-school wheeze and evidence for their effectiveness
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Bush, A. (2019, March 28). Pre-school wheeze [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/MHNC6134.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Andrew Bush has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
Hi, I'm Professor Andrew Bush from Imperial College and the Royal Brompton Hospital.
In this talk, I propose to cover the very difficult subject of Preschool Wheeze.
0:13
I have no relevant or irrelevant conflicts of interest
with regards to this presentation.
0:20
The aims of the presentation are to discuss the differential diagnosis of preschool children
presenting with wheeze and associated respiratory symptoms.
I will set out pathology and components of wheezing diseases in preschool children
and how we should be measuring them in the 21st century.
I will review treatment approaches in light of this
and also new data on inhaled and oral corticosteroids and azithromycin in particular.
0:50
So what conditions may mimic preschool wheeze and when should we consider them?
0:57
Cough and wheezes, by-and-large,
fall into one of five categories,
and you use the skills of your history and physical examination
to determine which category the child falls into.
The first category is normal child,
and this is the hardest diagnosis of all
and one you'll spend your life trying to learn how to make.
The next category is serious illness.
This is rare, particular in primary care,
but it's essential to get it right –
things like cystic fibrosis,
tuberculosis; the conditions will vary across the world.
The next group is an asthma syndrome,
which I will discuss,
the next group are minor problems such as rhinitis or reflux,
which may mimic or exacerbate wheezing symptoms,
and finally, the child, or family in particular,
who are over-anxious.