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1. Introduction
2. PGx - a simpler complex trait?
3. Phenytoin pathways
4. Candidate genes for PGx
5. Identified PGx variants
6. Polymorphisms associated with PGx (1)
7. Polymorphisms associated with PGx (2)
8. Polymorphisms associated with PGx (3)
9. Summary of PGx polymorphism types
10. Candidate genes for PGx
11. A simpler complex trait?
12. Simpler, not simple
13. PGx - more basic research needed
14. Mapping strategies
15. Illustration of tagging SNPs
16. A paradigm for indirect assocation studies
17. Questions about ht mapping
18. Selection of tags
19. Condition for tSNP selection
20. GSK data set
21. Genes selected for GSK project
22. CYP2C 4-gene complex
23. A test of tSNP performance
24. Sample size and MAF
25. Initial genotyping density
26. Representing functional variation
27. Cosmopolitan SNPs
28. Tagging the major human DMEs (1)
29. Tagging the major human DMEs (2)
30. ABCB1
31. ABCB1 and epilepsy
32. C3435T and other candidate polymorphisms
33. Associated interval
34. Bayesian estimator of associated interval
35. Posterior odds of causality relative to C3435T
36. Posterior odds ratios under different conditions
37. Association of variants with drug-resistant epilepsy
38. Intermediate phenotypes deserve more attention
39. Acknowledgments

Topics Covered

• Pharmacogenetics: a simpler complex trait?
• Mapping strategies: map-based and sequence-based
• Tagging SNPs: definition and assessment
• Case study: tagging in 56 drug transport and metabolism genes
• tSNP efficiency: influence of sample size, SNP frequency and SNP density
• Case study: ABCB1 and anti-epileptic drug resistance
• Associated interval

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• David Goldstein (speaker): has no commercial relationships to disclose Ashik Mohamed (editor): has no commercial relationships to disclose