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Printable Handouts
Navigable Slide Index
- Introduction
- Lecture overview
- Prehistorical myeloma
- 1844 - the first modern description
- 1845 - Thomas Alexander McBean
- Epidemiology of multiple myeloma (MM)
- Burden of multiple myeloma in the USA
- Pathology of multiple myeloma
- Myeloma cells and the microenvironment
- Progression of plasma cell malignancy
- Progression of myeloma
- Causes of myeloma
- MGUS
- When to treat patients for myeloma
- Smouldering myeloma patients
- Biochemical hallmarks of myeloma
- Serum protein electrophoresis
- Serum free light chain assay
- Multiple organ systems affected
- Myeloma manifestations
- Osteolytic lesions in multiple myeloma
- STIR MRI patterns at diagnosis
- Genetics of multiple myeloma
- Revised-international staging system
- Myeloma: therapy principles
- IMWG criteria: myeloma requiring treatment
- Classic treatment framework
- Current treatment classes
- Initial therapy - induction
- Comparison of treatment methods
- Treatment response criteria in MM
- Relapse is the hallmark of MM
- Early relapse regimens
- Adjunctive treatment
- Multiple mechanisms of monoclonal antibodies
- How does MM evade the immune response?
- Allogenic transplant can cure some patients
- Chimeric antigen receptor (CAR) therapy
- Lecture summary
Topics Covered
- Introduction to the diagnosis of multiple myeloma
- Related plasma cell disorders such as MGUS/Smouldering Myeloma
- Diagnostic criteria
- Staging and prognosis including revised international staging (RIS)
- Essential laboratory tests
- Cytogenetics and chromosomal changes in myeloma
- Overview of myeloma treatment
- New and emerging drugs in myeloma
Talk Citation
Hari, P. (2019, February 28). Multiple myeloma: an overview [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 22, 2024, from https://doi.org/10.69645/MMLA7265.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Parameswaran Hari has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Cancer
Transcript
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0:00
Good morning. I am Dr. Parameswaran Hari,
a professor of medicine at
the Medical College of Wisconsin in Milwaukee Wisconsin, United States.
The goal today is to discuss the topic of
"Multiple Myeloma" and give you a broad overview of this disease.
0:17
We'll do this in sequence.
We'll talk with the historical context of multiple myeloma and its epidemiology.
We'll talk about the pathology manifestations
and the spectrum of this disease and it's natural history.
Then we will go into diagnosis and investigations
that are needed to be performed on patients with myeloma.
We'll discuss treatment goals, mode of care.
Treatment itself will be subdivided into topics such as;
transplantation, maintenance, and treatment of relapse of multiple myeloma.
0:47
Multiple myeloma as a disease has been present for many, many centuries.
There's evidence from the ancient Egyptians and the tombs in Egypt
that multiple myeloma may have been present in some of the people who are buried there.
In the United States and among the Native American skeletons,
we have evidence of multiple myeloma dating back at least to 200 to 900 AD.
This picture is of a skull of a 25-year-old female Native American person with
lytic lesions that you can see as small holes in
the skull bones that's estimated to be between 200 to 900 AD.
1:23
The first modern description of myeloma comes from 1844.
This was reported in London and
the publication is attached here with Dr. Samuel Solly of London,
United Kingdom described two female patients with
multiple bone fractures which he called "Mollities Ossium" or melting bones.
The case that was reported extensively is that of a lady named
Sarah Newbury who is historically
credited as the first patient with a reported case of myeloma.