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Navigable Slide Index

1. Introduction
2. Oxidative stress
3. Cellular effects of oxygen radicals
4. Sources of ROS - hypoxia
5. Sources of ROS - inflammation
6. Sources of ROS - UV radiation
7. Consequence of hyperoxia
8. Are ROS useful?
9. ROS in fertilization
10. ROS in embryogenesis
11. ROS in implantation
12. ROS in limb bud formation
13. ROS: good or bad? a balancing act
14. Oxidative stress induces antioxidant defense
15. Important antioxidants
16. Antioxidant vitamins
17. Less traditional antioxidants
18. Bilirubin as an antioxidant?
19. Heme oxygenase regulates bilirubin production
20. HO-1 gene
21. Oxidative regulation of HO-1 (1)
22. Oxidative regulation of HO-1 (2)
23. HO-1 luciferase reporter construct
24. Bench-top small animal imaging system
25. HO-1/Luc activation in hyperoxia
26. HO-1 knockouts
27. Nitric oxide: the good
28. Developmental regulation of NO byproducts
29. Antioxidants: the more the merrier?
30. Nitric oxide: the bad
31. NO in neonatal chronic lung disease
32. ROS and Down syndrome
33. Deleterious effects of excess CuZn SOD
34. Do ROS contribute to neonatal diseases?
35. Upregulation of antioxidant defenses before birth
36. Prematurity = disrupted development
37. Examples for oxidative insults
38. ROS in bronchopulmonary dysplasia (BPD)
39. ROS in periventricular leukomalacia (PVL)
40. ROS in necrotizing enterocolitis (NEC)
41. ROS in retinopathy of prematurity (ROP)
42. Clinical trials with antioxidants in neonates
43. Therapeutic interventions: superoxide dismutase
44. Therapeutic interventions: N-acetylcysteine
45. Therapeutic interventions: glutathione
46. Therapeutic interventions: vitamin C
47. Therapeutic interventions: vitamin E
48. Therapeutic interventions: nitric oxide
49. Clinical trials of NO - no benefits
50. Clinical trials of NO - worrisome effect
51. Clinical trials of NO - beneficial effect
52. Clinical trials of NO - lung protective effect
53. Clinical trials of NO - neuroprotective effects
54. Is NO related to decrease oxidative stress?
55. No impresive beneficial effects for antioxidants
56. Therapeutic interventions: what do we do?
57. Balance
58. Acknowledgments

Topics Covered

• Cellular effects of oxygen radicals
• Sources of ROS
• Hyperoxia
• ROS in various processes
• ROS: good or bad?
• Important antioxidants
• Antioxidant vitamins
• Less traditional antioxidants
• HO-1 gene
• Nitric oxide
• ROS and Down syndrome
• ROS contribution to neonatal diseases
• Clinical trial with antioxidants in neonates

Links

Series:

• Free Radicals and the Oxygen Paradox

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Gynaecology & Obstetrics

Talk Citation

Dennery, P. (2007, November 1). Oxidative stress in development and neonatal diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/PASL6836.
Export Citation (RIS)

Publication History

• Published on November 1, 2007
• Archived on October 28, 2018

Financial Disclosures

• Dr. Phyllis Dennery has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.