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- Foundations of Obesity
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1. What is obesity - epidemiology
- Prof. Alexandra Blakemore
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2. What is obesity - definition
- Dr. Andrew Walley
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3. What is obesity - physiology
- Prof. Alexandra Blakemore
- Developmental Origins and Early-Life Obesity
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4. Obesity: the role of fetal programming
- Dr. Jess Buxton
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5. Childhood obesity
- Dr. Mars Skae
- Biological Mechanisms of Obesity
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6. Adipose tissue biology
- Dr. Constantinos Christodoulides
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7. Hormones, feeding and animal models
- Prof. Carel le Roux
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8. Metabolic communication in development and control of obesity 1
- Prof. Elaine Holmes
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9. Metabolic communication in development and control of obesity 2
- Prof. Elaine Holmes
- Genetics and Epigenetics
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10. Genetics of monogenic obesity 1
- Prof. Dr. Johannes Hebebrand
- Prof. Dr. Anke Hinney
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11. Genetics of monogenic obesity 2
- Prof. Dr. Johannes Hebebrand
- Prof. Dr. Anke Hinney
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12. Genetic epidemiology of obesity 1
- Prof. Ruth Loos
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13. Genetic epidemiology of obesity 2
- Prof. Ruth Loos
- Behaviour, Psychology and Neuroscience
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14. Obesity and psychology
- Dr. Samantha Scholtz
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15. Dysregulated eating behaviour, eating disorders and obesity
- Prof. Ulrike Schmidt
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16. Obesity and the hedonic response 1
- Dr. Tony Goldstone
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17. Obesity and the hedonic response 2
- Dr. Tony Goldstone
- Obesity-related Disease and Clinical Consequences
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19. Obesity and asthma
- Prof. Anne Dixon
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20. Obesity and women’s health 1: female obesity
- Dr. Thomas Barber
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21. Obesity and women’s health 2: polycystic ovary syndrome
- Dr. Thomas Barber
- Treatment of Obesity
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22. Obesity management: lifestyle and bariatric surgery 1
- Prof. John Wilding
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23. Exercise interventions and epidemiological approaches in obesity
- Prof. Jennifer Kuk
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24. Obesity management: lifestyle and bariatric surgery 2
- Prof. John Wilding
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25. Pharmacotherapy for obesity: why it is needed
- Prof. Joe Proietto
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26. Pharmacotherapy for obesity: hunger suppressors
- Prof. Joe Proietto
- Integration and Future Directions
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27. Obesity, present and future therapies
- Prof. Sir Stephen Bloom
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28. Towards personalised medicine in obesity
- Prof. Alexandra Blakemore
- Archived Lectures *These may not cover the latest advances in the field
Printable Handouts
Navigable Slide Index
- Introduction
- Disclosure
- Long term effects of weight loss – diet therapy
- Long term effects of weight loss – physical activity
- Long term effects of weight loss – behavior therapy
- Why do diets nearly always fail?
- Regulation of body weight
- Changes in leptin levels with dieting
- Ghrelin levels after diet-induced weight loss
- Body weight is defended
- Mean changes in body weight and leptin levels
- Mean fasting and postprandial levels of hormones
- Fasting and postprandial ratings of hunger
- Study conclusions
- Body weight and changes in energy expenditure
- Changes in energy and weight
- Total, resting and non-resting energy expenditure
- Persistent metabolic adaptation
- Leptin levels
- Stratagies for long term weight loss maintenance
- Lifestyle advice
Topics Covered
- Long term effects of weight loss
- Diet, physical activity and behavior therapy in weight loss
- Molecular regulation of body weight
- Changes in energy expenditure and persistent metabolic adaptation
- Strategies for long term weight loss maintenance
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Proietto, J. (2018, December 31). Pharmacotherapy for obesity 1 - the need for pharmacotherapy in weight management [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved July 27, 2026, from https://doi.org/10.69645/QCLR8903.Export Citation (RIS)
Publication History
Financial Disclosures
- Advisory Board: Novo Nordisk and iNOVA
Pharmacotherapy for obesity 1 - the need for pharmacotherapy in weight management
A selection of talks on Metabolism & Nutrition
Transcript
Please wait while the transcript is being prepared...
0:00
This lecture is about pharmacotherapy for obesity.
I'm Joe Proietto.
I am Professor Emeritus at the University of Melbourne and
the head of the Weight Control Clinic at Austin Health in Melbourne.
I'm also chair of the Clinical Care Committee of World Obesity.
0:22
Before I start, I need to declare that I am currently chair
of the Medical Advisory Board for Liraglutide in Australia for Novo Nordisk.
I've also given lectures on Weight Management
for iNova who market phentermine in Australia.
0:47
Some years ago, in fact in 2003
the National Health and Medical Research Council in Australia
developed evidence-based guidelines for the management of obesity.
As part of that,
they've reviewed literature on various strategies for weight loss including: diets,
exercise and psychological treatments and investigated
the acute weight losses and then the two year outcomes of those weight loss strategies.
In this slide, you see the effects of diet therapies on the left-hand column.
You can see the types of diets that were found in the literature including;
low fat, low energy, very low energy,
meal replacements and there are different degrees of a fat losses from
3.9 which had low-fat diets to 11.8 with very low energy diets.
But the weight-loss at two years was less as most patients regained the weight.