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1. Introduction
2. Radicals and diseases
3. Forms of reactive oxigen species (ROS)
4. Outline
5. Names and abbreviations
6. Historical overview
7. The paradox of oxygen
8. Cu,Zn-superoxide dismutase (SOD)
9. Fe,Mn-SOD
10. Superoxide formation (1)
11. Superoxide formation (2)
12. The Haber-Weiss reaction
13. Radical chemistry: the Fenton reaction
14. History of Fenton reaction
15. The product of Fenton reaction
16. Fenton reaction discovery - a case of serendipity
17. Radical chemistry: the Haber-Weiss cycle
18. Characteristics of radicals involved in the cycle
19. Role of iron ions in the cycle
20. Researchers who contributed to cycle discovery
21. Criticism by P. George
22. Two possible mechanisms
23. Conclusion of P. George research
24. Mechanism for hydrogen-peroxide decomposition
25. Haber-Weiss cycle: conclusions
26. Kinetics of the Fenton reaction
27. Possible oxidizing agents in the Fenton reaction
28. Remarks and questions regarding Fenton reaction
29. Fenton reaction vs. reacion with catalase
30. In vivo protection: SOD or catalase?
31. Generation of radicals by ionising radiation
32. Interconversion of radicals
33. Generation of radicals by flash photolysis
34. Detection of radicals
35. Thermodynamics of superoxide
36. Electrode potentials
37. Redox potential of superoxide/dioxygen couple (1)
38. Redox potential of superoxide/dioxygen couple (2)
39. Gibbs free energy for superoxide redox (1)
40. Gibbs free energy for superoxide redox (2)
41. Oxidation state diagram for oxygen
42. Reduction of hydrogen-peroxide by superoxide
43. Superoxide reactivity and catalysis by SOD
44. Hydrogen-peroxide properties
45. Hydroxyl radical properties
46. Radicals in cells - summary
47. Finding the role of SOD in physiology
48. Formation of peroxynitrite
49. Peroxynitrite formation in cells (1)
50. Nitrogen-monoxide in living cells
51. Peroxynitrite formation in cells (2)
52. Properties of peroxynitrite
53. Peroxynitrite and carbon-dioxide
54. Concluding remarks

Topics Covered

• Oxy radicals and peroxides: superoxide, hydrogen peroxide, hydroxyl, peroxynitrite
• Generation by ionizing radiation and by flash photolysis
• Reactivity
• Thermodynamics, electrode potentials and kinetics
• Fenton chemistry

Links

Series:

• Free Radicals and the Oxygen Paradox

Categories:

• Biochemistry

Talk Citation

Koppenol, W. (2007, November 1). The chemistry and biochemistry of partially reduced oxygen species [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/ADUM2412.
Export Citation (RIS)

Publication History

• Published on November 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Willem Koppenol has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.