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Navigable Slide Index

1. Introduction
2. Why we all get rusty
3. The oxygen paradox
4. The oxygen paradox explained
5. Fire
6. Origin of oxygen and why it is dangerous (1)
7. Origin of oxygen and why it is dangerous (2)
8. Blue-green algae (cyanobacteria) in the oceans
9. Plants
10. Oxygen is the waste product of photosynthesis
11. Carbon-oxygen balance
12. Oxygen as the world's first major pollutant
13. Aerobic respiration
14. Free radicals, oxidants and oxidative stress
15. Free radicals in biology
16. Major reactive oxygen/nitrogen species
17. Sources of free radicals and RO and RN species
18. Radiation
19. Smog
20. Intermediates of NO oxidation
21. Food and drinks as a source of free radicals
22. Environmental toxins
23. Metabolic sources of free radicals
24. Electron micrograph of a mitochondrion
25. Mitochondrial electron transport chain
26. The univalent pathway for oxygen reduction
27. Other metabolic sources of free radicals
28. Neutrophyl phagocytosis and cytotoxicity
29. The NADPH-oxidase system
30. Hydrogen peroxide generation by phagocytes
31. Hypochlorous acid generation by phagocytes
32. Medical and dental sources of free radicals
33. Drugs we need to consider
34. Anthracycline reaction with NADH-dehydrogenase
35. Oxygen-derived radicals and tissue injury
36. All reduced carbons are substrates for oxidation
37. DNA damage and oxygen radical toxicity
38. Types of oxidative damage to DNA
39. Membrane lipid peroxidation
40. Oxidative damage to proteins
41. Chemistry experiments with free radicals
42. Is that really all there is?
43. Antioxidants and vitamins
44. Antioxidant compounds
45. Natural alpha-tocopherol
46. Antioxidant enzymes
47. Enzymatic defense mechanisms
48. The dismutation of superoxide
49. Mechanisms of antioxidant enzymes
50. Cycle of hydrogen peroxide reduction
51. Dismutation of superoxide
52. Keeping balance between damage and defence
53. Antioxidant defense and repair systems
54. Damage removal, repair and replacement systems
55. DNA repair
56. Common mechanisms of DNA damage and repair
57. Lipolysis and repair of oxidized lipids
58. Phospholipase A2
59. Activity of phospholipase A2
60. Proteolytic degradation of oxidized proteins
61. Proteasome
62. Degradation of oxidized proteins by proteasome (1)
63. Degradation of oxidized proteins by proteasome (2)
64. Protection of mitochondrial proteins
65. Lon protease
66. Structure of Lon protease
67. Oxidative stress - review
68. Adaptation to oxidative stress
69. Adaptation to hydrogen peroxide in HA-1 cells
70. Hydrogen peroxide affects cell growth and viability
71. Altered gene expression and oxidative stress (1)
72. Altered gene expression and oxidative stress (2)
73. Spectrum of oxidative stress responses
74. Cellular responses to oxidative stress - review
75. The importance of growth-arrest
76. Effects of free radicals and oxidative stress
77. The free radical theory of aging
78. Fountain of youth'' and anti-aging drugs
79. Oxidative stress in aging
80. Free radicals and disease

Topics Covered

• The oxygen paradox
• Oxygen origin
• Free radicals, oxidants and oxidative stress
• Sources of free radicals
• Environmental toxins
• Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation
• Medical and dental sources of free radicals: x-rays, g-rays, drugs
• DNA damage and oxygen radical toxicity
• Antioxidant compounds and enzymes
• The dismutation of superoxide
• Mechanisms of antioxidant enzymes
• Antioxidant defense and repair systems
• Removal of oxidized DNA bases and DNA repair
• Lipolysis and the repair of oxidized lipids and lipid membranes
• Selective proteolytic degradation of oxidized proteins
• The LON protease
• Adaptation to oxidative stress
• Long-term effects of free radicals and oxidative stress: aging and disease

Links

Series:

• Free Radicals and the Oxygen Paradox

Categories:

• Biochemistry

Talk Citation

Davies, K. (2007, November 1). Introduction to free radicals and the oxygen paradox: oxidative stress in biology, aging & disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/KAIB7199.
Export Citation (RIS)

Publication History

• Published on November 1, 2007

Financial Disclosures

• Professor Kelvin Davies has no commercial/financial relationships to disclose