• General Virology
• 46 min
  1. Principles of virology

  • Prof. Vincent Racaniello
• 36 min
  2. The type I interferon system and viruses

  • Dr. Adolfo Garcia-Sastre
• 45 min
  3. Immune responses to viruses

  • Prof. Paul Klenerman
• Emerging Pathogens
• 29 min
  4. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide

  • Dr. Marietjie Venter
  • Mrs. Orienka Hellferscee
• 37 min
  5. Emerging respiratory viruses - discoveries between 2001 and 2005

  • Prof. Ron Fouchier
• 28 min
  6. Usage of vaccines and therapeutics in public health emergencies 1

  • Prof. Gary Kobinger
• 39 min
  7. Usage of vaccines and therapeutics in public health emergencies 2

  • Prof. Gary Kobinger
• 50 min
  8. Influenza virus pandemics: past and future

  • Prof. Peter Palese
• 63 min
  9. SARS-CoV and other emerging coronaviruses

  • Prof. Ralph Baric
• 36 min
  10. Dengue, Zika and Chickungunya viruses

  • Prof. Ana Fernandez-Sesma
• 43 min
  11. Paramyxoviruses: biology & pathogenesis

  • Prof. Benhur Lee
• 36 min
  12. Antiviral drugs (non-HIV)

  • Prof. Megan Shaw
• 41 min
  13. Biodefense challenges

  • Dr. David Franz
• Important Pathogens and their Diseases
• 38 min
  14. Natural history and pathogenesis of herpes virus infections

  • Prof. Richard Whitley
• 40 min
  15. Cytomegalovirus biology

  • Prof. Domenico Tortorella
• 46 min
  16. Hepatitis C virus: discovery, cure and protection

  • Dr. Matthew Evans
• 32 min
  17. Fundamentals of HIV biology

  • Prof. Viviana Simon
• 44 min
  18. Measles

  • Prof. Diane E. Griffin
• 42 min
  19. Monkeypox virus, vaccines, and therapeutics

  • Prof. Rachel Roper
• New Frontiers
• 45 min
  20. HPV vaccines to prevent cervical cancer and other HPV-associated diseases

  • Dr. John Schiller
• 55 min
  21. Prevention of Varicella and Zoster by vaccination: Now you see it, now you don't

  • Prof. Anne Gershon
• 30 min
  22. Viruses as anticancer weapons

  • Prof. Roberto Cattaneo
• 48 min
  23. Novel approaches to diagnosis of viral infections

  • Prof. W. Ian Lipkin
• 36 min
  24. The Global Virus Network: collaboration to address pandemic and regional threats

  • Prof. Sten H. Vermund
• 31 min
  25. Elite controllers of HIV: from discovery to future therapies

  • Prof. Bruce Walker
• Archived Lectures *These may not cover the latest advances in the field
• 43 min
  26. Principles of virology I

  • Prof. Richard Condit
• 43 min
  27. Principles of virology II

  • Prof. Richard Condit
• 36 min
  28. Complex DNA viruses: herpes virus

  • Dr. John Blaho
• 38 min
  29. Adeno-associated viruses (AAV)

  • Prof. Kenneth Berns
• 60 min
  30. Poxviruses: smallpox (variola), vaccinia and monkeypox

  • Prof. Paula Traktman
• 26 min
  31. Can HPV testing be the sole primary cervical screening modality?

  • Prof. Jack Cuzick
• 29 min
  32. From viruses to oncolytics

  • Prof. Roberto Cattaneo
• 38 min
  33. Non HIV antivirals

  • Prof. Mary Klotman
• 42 min
  34. Gastroenteritis viruses

  • Prof. Mary Estes
• 46 min
  35. Biodefense challenges

  • Dr. Connie Schmaljohn
• 32 min
  36. Papillomaviruses and HPV vaccination to prevent cervical cancer and other HPV-associated diseases

  • Dr. Douglas Lowy
• 49 min
  37. The past, present and future of vaccination

  • Prof. Stanley Plotkin
• 41 min
  38. Filoviruses

  • Dr. Christopher Basler
• 41 min
  39. Bunyaviruses

  • Prof. Richard Elliott
• 41 min
  40. The immunobiology of HIV

  • Prof. Norman Letvin
• 59 min
  41. Hepatitis C and HCV

  • Prof. Stanley Lemon

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Disclosure
3. Outline of presentation
4. Cancers attributable to HPV infection
5. HPV types associated with cervical cancer
6. Progression of cervical HPV infections to cancer
7. Natural history of cervical HPV infection
8. Key features of HPV pathogenesis
9. Genital warts
10. Laboratory of cellular oncology, CCR, NCI
11. Developing preventive HPV vaccine challenges
12. A prophylactic vaccine
13. Formation of papillomavirus virions
14. L1 self-assembles to form virus-like particles
15. L1 VLP induction of neutralizing antibodies
16. Systemic VLP vaccination in animal models
17. Two HPV VLP vaccines are under development
18. Merck: phase III prophylactic efficacy results
19. Possible long term protection by HPV vaccine
20. Cross-protection against other HPV types
21. Preventing HPV cervical disease efficacy
22. HPV life cycle
23. How could vaccine prevent mucosal infection
24. How could vaccine prevent cutaneous infection
25. L1 VLPs are unlikely to be directly therapeutic
26. Will the vaccines influence prevalent infection?
27. Outstanding medical issues
28. Regulatory status of HPV VLP vaccines
29. Gardasil phase III adolescent study
30. Percentage of sexually active teenagers in USA
31. Disease progression by HPV status at entry
32. We can't give up screening
33. Cervical cancer prevention by Pap screening
34. HPV-based cervical cancer prevention strategy
35. HPV vaccination in developing nations
36. Limitations of current VLP vaccines
37. Potential reduction in cervical cancer
38. Papillomaviruses neutralized by BPV1 L2
39. Vaccination with L1-Salmonella live vaccine
40. Summary and conclusions

Topics Covered

• Cervical cancer is attributable to multiple HPV types; HPV16 predominates
• Cervical cancer: time line of cervical HPV infections, progression and natural history
• Key features of HPV pathogenesis
• Challenges to development of a preventive HPV vaccine
• A prophylactic vaccine
• Formation of papillomavirus virions
• Two distinct HPV VLP vaccines are under commercial development
• Partial crossprotection against incident infection by other high risk HPV types
• Overall efficacy in preventing HPV cervical disease attributable to incident infection
• HPV life cycle
• How could IM injection of a VLP vaccine prevent mucosal or cutaneous infection at the cervix?
• Outstanding medical issues
• Regulatory status of HPV VLP vaccines
• Pap smear screening without vaccination would prevent more cervical cancer deaths than HPV16/18 vaccination without pap screening
• Limitations of current VLP vaccines

Links

Series:

• Viruses and Viral Diseases

Categories:

• Immunology
• Microbiology
• Reproduction & Development

Therapeutic Areas:

• Gynaecology & Obstetrics
• Infectious Diseases
• Vaccines

Talk Citation

Lowy, D. (2007, October 1). Papillomaviruses and HPV vaccination to prevent cervical cancer and other HPV-associated diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/YOLG3023.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on September 26, 2018

Financial Disclosures

• Dr. Douglas Lowy has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.