Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. Diarrhea is a health problem worldwide
4. Viruses causing diarrhea in human
5. Rotavirus (RV)
6. Epidemiology
7. Rotavirus pathogenesis
8. Rotaviruses infect mature enterocytes
9. RV-gnotiobiotic piglets
10. Rotavirus infection in calves
11. Effects of Rotavirus infection
12. Rotavirus genes and proteins
13. Rotavirus replication
14. Rotavirus life cycle
15. Unique particle assembly process
16. NSP4: an intracellular receptor and enterotoxin
17. NSP4-inoculated mouse
18. Intestine of NSP4-inoculated mouse
19. Properties of Rotavirus enterotoxin
20. How does the Rotavirus enterotoxin NSP4 act?
21. Effects of RV infection of polarized epithelial cells
22. How does Rotavirus cause diarrhea - summary
23. New unexpected information about RV replication
24. Treatment and vaccines
25. A child with RV infection
26. Oral rehydration therapy
27. A child after rehydration therapy
28. Current status of RV vaccines
29. Rotavirus - conclusions
30. Norwalk virus (NV)
31. Norovirus gastroenteritis
32. Norovirus background
33. Norovirus pathogenesis
34. Clinical responses of two adult volunteers given NV
35. 1970s NV studies
36. Challenges studying Norwalk virus (NV)
37. Virus-like particles (VLPs)
38. Norwalk VLPs hemagglutinate red blood cells
39. What is the H antigen?
40. FUT2 genotype versus NV challenge outcome
41. Is host susceptibility similar for all noroviruses?
42. Summary: Noroviruses
43. Remained questions

Topics Covered

• Viruses causing diarrhea
• Epidemiology
• Rotavirus pathogenesis
• Rotavirus infection in calves
• Rotavirus genes and proteins
• Rotavirus replication
• NSP4
• Properties of rotavirus enterotoxin
• Treatment and vaccines
• Norovirus
• Norovirus pathogenesis
• Challenges studying Norwalk virus

Links

Series:

• Viruses and Viral Diseases

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Gastroenterology & Nephrology
• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Mary Estes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.