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1. Introduction
2. World-wide AIDS epidemic
3. HIV genomic organization
4. HIV virion structure
5. Requirements for HIV entry into cells
6. HIV life cycle
7. Primary HIV infection
8. Clinical consequences of HIV infection
9. HIV genetic variation: molecular mechanisms
10. Genetic diversity - clades
11. HIV transmission
12. Cell-free versus cell-associated transmission
13. Mechanisms of immune containment
14. Simian immunodeficiency viruses
15. Origin of HIV-1: SIVcpz
16. AIDS animal models
17. Antibody response to HIV
18. CD8+ lymphocytes inhibit HIV replication
19. CTL emergence precedes early SIV containment
20. High frequency CTL - clinical status association
21. Early SIV containment and CD8+ lymphocytes
22. Cellular immune response to HIV
23. Failure of HIV control by CTL
24. Variation in clinical course
25. Anti-retroviral therapy
26. Failure of traditional vaccine strategies
27. Novel vaccine strategies
28. CTL-based vaccine in SIV challenge monkeys
29. Future

Topics Covered

• HIV molecular biology
• HIV entry into cells
• Immune consequences of HIV infection
• Animal models of HIV infection
• Immune containment of HIV
• HIV vaccine development

Links

Series:

• Viruses and Viral Diseases

Categories:

• Immunology
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on April 30, 2020

Financial Disclosures

• Prof. Norman Letvin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.